untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:17:53Z</responseDate>
<request identifier=oai:HAL:hal-01668314v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01668314v1</identifier>
<datestamp>2018-01-16</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-PARIS7</setSpec>
<setSpec>collection:DSIMB</setSpec>
<setSpec>collection:UNIV-SAVOIE</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UNIV-ST-ETIENNE</setSpec>
<setSpec>collection:UNIV-REUNION</setSpec>
<setSpec>collection:UGA</setSpec>
<setSpec>collection:UNIV-LYON1</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease</title>
<creator>Möckesch, Berenike</creator>
<creator>Connes, Philippe</creator>
<creator>Charlot, Keyne</creator>
<creator>Skinner, Sarah</creator>
<creator>Hardy-Dessources, Marie</creator>
<creator>Romana, Marc</creator>
<creator>Jumet, Stéphane</creator>
<creator>Petras, Marie</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Martin, Cyril</creator>
<creator>Tressieres, Benoît</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hue, Olivier</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Antoine, Sophie</creator>
<creator>Pialoux, Vincent</creator>
<contributor>Université des Antilles (Pôle Guadeloupe) ; Université des Antilles (UA)</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Biologie intégrée du globule rouge ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre de Recherche et d'Innovation sur le Sport (EA647) (CRIS) ; Université Claude Bernard Lyon 1 (UCBL)</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ) ; Université Claude Bernard Lyon 1 (UCBL) - Université Jean Monnet [Saint-Étienne] (UJM) - Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])</contributor>
<description>International audience</description>
<source>ISSN: 0007-1048</source>
<source>EISSN: 1365-2141</source>
<source>British Journal of Haematology</source>
<publisher>Wiley</publisher>
<identifier>hal-01668314</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668314</identifier>
<source>https://hal.univ-antilles.fr/hal-01668314</source>
<source>British Journal of Haematology, Wiley, 2017, 178 (3), pp.468 - 475. 〈10.1111/bjh.14693〉</source>
<identifier>DOI : 10.1111/bjh.14693</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14693</relation>
<language>en</language>
<subject lang=en>sickle cell disease</subject>
<subject lang=en> haemolysis</subject>
<subject lang=en> vascular function.</subject>
<subject>[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Oxidative stress and haemolysis-associated nitric oxide (NO) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia (SS). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease (SC). Microvascular response to heat (using Laser Doppler flowmetry on finger), oxidative stress biomarkers, NO metabolites, endothelin-1 and haematological parameters were compared between patients with SS and SC. Vascular function, oxidative and nitrosative markers were also measured in healthy (AA) children. SS and SC had increased plasma advanced oxidation protein products (AOPP), malondialdehyde, plasma antioxidant activities and NO end products, compared to AA. SC had lower catalase activity compared to AA and SS. Haemolytic rate, glutathione peroxidase and nitrotyrosine concentrations were significantly increased in children with SS compared to SC and AA. SS and SC had impaired microvascular reactivity compared to AA. In SS, the plateau phase of the response to local thermal heating was negatively associated with nitrotyrosine and AOPP. No association between vascular function parameters and oxidative stress markers was observed in SC. Mild haemolysis in SC, compared to SS, may limit oxidative and nitrosative stress and could explain the better preserved microvascular function in this group.</description>
<date>2017-08</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
