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<title lang=en>Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.</title>
<creator>Cousin, Fabien, </creator>
<creator>Jouan-Lanhouet, Sandrine</creator>
<creator>Dimanche-Boitrel, Marie-Thérèse</creator>
<creator>Corcos, Laurent</creator>
<creator>Jan, Gwénaël</creator>
<contributor>Science et Technologie du Lait et de l'Oeuf (STLO) ; Institut National de la Recherche Agronomique (INRA) - AGROCAMPUS OUEST</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Université de Brest (UBO)</contributor>
<contributor>: This work was financed by Conseil Re'gional de Bretagne through the CBB de'veloppement call for projects and by the Centre National Interprofessionnel de l'E'conomie Laitie're (CNIEL) through by the Scientific Committee of Syndifrais call for projects. Research in the IRSET group was supported by grants from the Ligue Nationale Contre le Cancer (the Coˆte d'Armor, Ille et Vilaine, Morbihan, Vende'e and Sarthe Comittees), INSERM, University of Rennes 1 and the Region Bretagne. FJC received a grant from CNIEL (doctoral fellowship). SJL was supported by the Association pour la Recherche sur le Cancer (doctoral fellowship). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00871491</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871491</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871491/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871491/file/Milk_Fermented_by_Propionibacterium_freudenreichii.accepted.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00871491</source>
<source>PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e31892. 〈10.1371/journal.pone.0031892〉</source>
<identifier>DOI : 10.1371/journal.pone.0031892</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0031892</relation>
<identifier>PUBMED : 22442660</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22442660</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Gastric cancer is one of the most common cancers in the world. The "economically developed countries" life style, including diet, constitutes a risk factor favoring this cancer. Diet modulation may lower digestive cancer incidence. Among promising food components, dairy propionibacteria were shown to trigger apoptosis of human colon cancer cells, via the release of short-chain fatty acids acetate and propionate. METHODOLOGY/PRINCIPAL FINDINGS: A fermented milk, exclusively fermented by P. freudenreichii, was recently designed. In this work, the pro-apoptotic potential of this new fermented milk was demonstrated on HGT-1 human gastric cancer cells. Fermented milk supernatant induced typical features of apoptosis including chromatin condensation, formation of apoptotic bodies, DNA laddering, cell cycle arrest and emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet, reactive oxygen species accumulation, mitochondrial transmembrane potential disruption, caspase activation and cytochrome c release. Remarkably, this new fermented milk containing P. freudenreichii enhanced the cytotoxicity of camptothecin, a drug used in gastric cancer chemotherapy. CONCLUSIONS/SIGNIFICANCE: Such new probiotic fermented milk may thus be useful as part of a preventive diet designed to prevent gastric cancer and/or as a food supplement to potentiate cancer therapeutic treatments.</description>
<date>2012</date>
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