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<publisher>HAL CCSD</publisher>
<title lang=en>Maternal fish and shellfish consumption and wheeze, eczema and food allergy at age two: a prospective cohort study in Brittany, France.</title>
<creator>Pelé, Fabienne</creator>
<creator>Bajeux, Emma</creator>
<creator>Gendron, Hélène</creator>
<creator>Monfort, Christine</creator>
<creator>Rouget, Florence</creator>
<creator>Multigner, Luc</creator>
<creator>Viel, Jean-François</creator>
<creator>Cordier, Sylvaine</creator>
<contributor>Faculté de médecine ; Université de Rennes 1 (UR1)</contributor>
<contributor>Service d ' Epidémiologie et de Santé Publique ; CentreHospitalier Universitaire de Rennes</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service Pédiatrie ; Centre Hospitalier Universitaire de Rennes</contributor>
<contributor>We are grateful to the families that participated in the study. We thank Veronique Villalon for her help and Jo Ann Cahn for her careful revision of the manuscript. The financial support from the National Institute for Public Health Surveillance (InVS), the Ministry of Labor, and the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) is acknowledged.</contributor>
<description>International audience</description>
<source>ISSN: 1476-069X</source>
<source>Environmental Health</source>
<publisher>BioMed Central</publisher>
<identifier>inserm-00926282</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00926282</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00926282/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00926282/file/1476-069X-12-102.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00926282</source>
<source>Environmental Health, BioMed Central, 2013, 12 (1), pp.102. 〈10.1186/1476-069X-12-102〉</source>
<identifier>DOI : 10.1186/1476-069X-12-102</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1186/1476-069X-12-102</relation>
<identifier>PUBMED : 24295221</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24295221</relation>
<language>en</language>
<subject lang=en>Fish intake</subject>
<subject lang=en>Shellfish intake</subject>
<subject lang=en>Pregnancy</subject>
<subject lang=en>Wheeze</subject>
<subject lang=en>Allergy</subject>
<subject lang=en>Children</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Environmental exposures, including dietary contaminants, may influence the developing immune system. This study assesses the association between maternal pre-parturition consumption of seafood and wheeze, eczema, and food allergy in preschool children. Fish and shellfish were studied separately as they differ according to their levels of omega-3 polyunsaturated fatty acids (which have anti-allergic properties) and their levels of contaminants. METHODS: The PELAGIE cohort included 3421 women recruited at the beginning of pregnancy. Maternal fish and shellfish intake was measured at inclusion by a food frequency questionnaire. Wheeze, eczema, and food allergy were evaluated by a questionnaire completed by the mother when the child was 2 years old (n = 1500). Examination of the associations between seafood intake and outcomes took major confounders into account. Complementary sensitivity analyses with multiple imputation enabled us to handle missing data, due mostly to attrition. RESULTS: Moderate maternal pre-parturition fish intake (1 to 4 times a month) was, at borderline significance, associated with a lower risk of wheeze (adjusted OR = 0.69 (0.45-1.05)) before age 2, compared with low intake (< once/month). This result was not, however, consistent: after multiple imputation, the adjusted OR was 0.86 (0.63-1.17). Shellfish intake at least once a month was associated with a higher risk of food allergy before age 2 (adjusted OR = 1.62 (1.11-2.37)) compared to low or no intake (< once/month). Multiple imputation confirmed this association (adjusted OR = 1.52 (1.05-2.21)). CONCLUSIONS: This study suggests that maternal pre-parturition shellfish consumption may increase the risk of food allergy. Further large-scale epidemiologic studies are needed to corroborate these results, identify the contaminants or components of shellfish responsible for the effects observed, determine the persistence of the associations seen at age 2, and investigate potential associations with health effects observable at later ages, such as allergic asthma.</description>
<date>2013</date>
<rights>info:eu-repo/semantics/OpenAccess</rights>
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