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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Micro- and macrovascular function in children with sickle cell anaemia and sickle cell haemoglobin C disease</title>
<creator>Möckesch, Berenike</creator>
<creator>Charlot, Keyne</creator>
<creator>Jumet, Stéphane</creator>
<creator>Romana, Marc</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Hardy-Dessources, Marie</creator>
<creator>Petras, Marie</creator>
<creator>Tressieres, Benoît</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hue, Olivier</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<creator>Antoine-Jonville, Sophie</creator>
<contributor>Université des Antilles (Pôle Guadeloupe) ; Université des Antilles (UA)</contributor>
<contributor>Institut National de la Santé et de la Recherche Médicale - INSERM ; Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)</contributor>
<contributor>This work was supported by the Academic Hospital of Pointe-à-Pitre, grant B91122-40 (2009-A00211-56)</contributor>
<description>International audience</description>
<source>ISSN: 1079-9796</source>
<source>EISSN: 1096-0961</source>
<source>Blood Cells, Molecules and Diseases</source>
<publisher>Elsevier</publisher>
<identifier>hal-01496857</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01496857</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01496857/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01496857/file/Mo%CC%88ckesch%20et%20al%20BCMD%20non%20apparent%20corrections%20final.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01496857</source>
<source>Blood Cells, Molecules and Diseases, Elsevier, 2017, 64, pp.23 - 29. 〈10.1016/j.bcmd.2017.02.001〉</source>
<identifier>DOI : 10.1016/j.bcmd.2017.02.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bcmd.2017.02.001</relation>
<language>en</language>
<subject lang=en>Vascular function</subject>
<subject lang=en> Sickle cell anaemia</subject>
<subject lang=en> Sickle cell haemoglobin C disease</subject>
<subject lang=en> Physical activity</subject>
<subject>[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>It is unclear whether vascular function is affected similarly in children with sickle cell anaemia (SS) and children with sickle haemoglobin C (SC) disease. Therefore, we compared micro and macrovascular functions in healthy (AA) children, children with SS and SC disease, and assessed their association with physical activity. Participants (24 SS, 22 SC and 16 AA), were compared in terms of 1) thermal hyperaemic response (finger pad warming to 42 °C) measured by Laser Doppler techniques, 2) arterial stiffness determined by pulse wave velocity, 3) daily energy expenditure related to moderate and intense physical activities estimated by questionnaire and 4) fitness level, evaluated by the six-minute walk test. Response to heating differed between SS, SC and controls. Peripheral microvascular reactivity was lower and pulse wave velocity higher in SS compared to AA. SC had blunted microvascular reactivity in response to heating compared to AA but pulse wave velocity was not different within the two groups. Physical activity and fitness levels were markedly lower in sickle cell patients compared to healthy controls but no association was observed with vascular function. Microvasodilatory reserve is decreased in both SS and SC patients but only SS patients were also characterised by impaired macrovascular function.</description>
<date>2017-05</date>
</dc>
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