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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength</title>
<creator>Cita, Kizzy-Clara</creator>
<creator>Brureau, Laurent</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Billaud, Marie</creator>
<creator>Connes, Philippe</creator>
<creator>Ferdinand, Séverine</creator>
<creator>Tressières, Benoit</creator>
<creator>Tarer, Vanessa</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Blanchet, Pascal</creator>
<creator>Elion, Jacques</creator>
<creator>Romana, Marc</creator>
<contributor>Observatoire Régional de la Santé de la Guadeloupe ; Observatoire Régional de la Santé de la Guadeloupe</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>CHU de Pointe-à-Pitre ; CHU de Pointe-à-Pitre</contributor>
<contributor>Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB) ; Université Bordeaux Segalen - Bordeaux 2 - CHU Bordeaux [Bordeaux] - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<contributor>Insern, UMR 763, Hôpital Robert Debré ; Université Paris Diderot - Paris 7 (UPD7)</contributor>
<contributor>Region Guadeloupe [J-2-1-J210002]</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01390971</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390971</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390971</source>
<source>PLoS ONE, Public Library of Science, 2016, 11 (5), pp.e0154866. 〈10.1371/journal.pone.0154866〉</source>
<identifier>DOI : 10.1371/journal.pone.0154866</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0154866</relation>
<identifier>PUBMED : 27145183</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27145183</relation>
<language>en</language>
<subject lang=en>alpha-thalassemia</subject>
<subject lang=en> risk-factors</subject>
<subject lang=en> disease</subject>
<subject lang=en> hydroxyurea</subject>
<subject lang=en> children</subject>
<subject lang=en> complications</subject>
<subject lang=en> prevalence</subject>
<subject lang=en> frequency</subject>
<subject lang=en> viscosity</subject>
<subject lang=en> rheology</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Objectives To investigate the association between priapism in men with sickle cell anemia (SCA) and hemorheological and hemolytical parameters. Materials and Methods Fifty-eight men with SCA (median age: 38 years) were included; 28 who had experienced priapism at least once during their life (priapism group) and 30 who never experienced this complication (control group). Twenty-two patients were treated with hydroxycarbamide, 11 in each group. All patients were at steady state at the time of inclusion. Hematological and biochemical parameters were obtained through routine procedures. The Laser-assisted Optical Rotational Cell Analyzer was used to measure red blood cell (RBC) deformability at 30 Pa (ektacytometry) and RBC aggregation properties (laser backscatter versus time). Blood viscosity was measured at a shear rate of 225 s(-1) using a cone/plate viscometer. A principal component analysis was performed on 4 hemolytic markers (i.e., lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), total bilirubin (BIL) levels and reticulocyte (RET) percentage) to calculate a hemolytic index. Results Compared to the control group, patients with priapism exhibited higher ASAT (p = 0.01), LDH (p = 0.03), RET (p = 0.03) levels and hemolytic indices (p = 0.02). Higher RBC aggregates strength (p = 0.01) and lower RBC deformability (p = 0.005) were observed in patients with priapism compared to controls. After removing the hydroxycarbamide-treated patients, RBC deformability (p = 0.01) and RBC aggregate strength (p = 0.03) were still different between the two groups, and patients with priapism exhibited significantly higher hemolytic indices (p = 0.01) than controls. Conclusion Our results confirm that priapism in SCA is associated with higher hemolytic rates and show for the first time that this complication is also associated with higher RBC aggregate strength and lower RBC deformability.</description>
<date>2016</date>
</dc>
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