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<title lang=en>Multiple exposures to indoor contaminants: Derivation of benchmark doses and relative potency factors based on male reprotoxic effects</title>
<creator>Fournier, Kevin</creator>
<creator>Tebby, Cleo</creator>
<creator>Zeman, Florence</creator>
<creator>Glorennec, Philippe</creator>
<creator>Zmirou-Navier, Denis</creator>
<creator>Bonvallot, Nathalie</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Modèles pour l'Ecotoxicologie et la Toxicologie (METO) ; Institut National de l'Environnement Industriel et des Risques (INERIS)</contributor>
<contributor>École des Hautes Études en Santé Publique [EHESP] (EHESP)</contributor>
<contributor>This work was supported by the French Ministry of Ecology: Primequal [Environnement Intérieur et Approches Innovantes], programme 190, THUR-BSAF action 13, sub-action 08.</contributor>
<description>International audience</description>
<source>ISSN: 0273-2300</source>
<source>EISSN: 1096-0295</source>
<source>Regulatory Toxicology and Pharmacology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01237085</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237085</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237085/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237085/file/Multiple%20exposures%20to%20indoor%20contaminants_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237085</source>
<source>Regulatory Toxicology and Pharmacology, Elsevier, 2016, 74, pp.23-30. 〈10.1016/j.yrtph.2015.11.017〉</source>
<identifier>DOI : 10.1016/j.yrtph.2015.11.017</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.yrtph.2015.11.017</relation>
<identifier>PUBMED : 26644063</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26644063</relation>
<language>en</language>
<subject lang=en>Benchmark doses</subject>
<subject lang=en>Cumulative risk assessment</subject>
<subject lang=en>mixture</subject>
<subject lang=en>Reproduction</subject>
<subject lang=en>Semi-volatile organic compounds</subject>
<subject lang=en>toxicity</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Semi-Volatile Organic Compounds (SVOCs) are commonly present in dwellings and several are suspected of having effects on male reproductive function mediated by an endocrine disruption mode of action. To improve knowledge of the health impact of these compounds, cumulative toxicity indicators are needed. This work derives Benchmark Doses (BMD) and Relative Potency Factors (RPF) for SVOCs acting on the male reproductive system through the same mode of action. We included SVOCs fulfilling the following conditions: detection frequency (>10%) in French dwellings, availability of data on the mechanism/mode of action for male reproductive toxicity, and availability of comparable dose-response relationships. Of 58 SVOCs selected, 18 induce a decrease in serum testosterone levels. Six have sufficient and comparable data to derive BMDs based on 10 or 50% of the response. The SVOCs inducing the largest decrease in serum testosterone concentration are: for 10%, bisphenol A (BMD10= 7.72E-07 mg/kg bw/d; RPF10= 7033679); for 50%, benzo[a]pyrene (BMD50= 0.030 mg/kg bw/d; RPF50= 1630), and the one inducing the smallest one is benzyl butyl phthalate (RPF10 and RPF50= 0.095). This approach encompasses contaminants from diverse chemical families acting through similar modes of action, and makes possible a cumulative risk assessment in indoor environments. The main limitation remains the lack of comparable toxicological data.</description>
<date>2016-02</date>
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