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<title lang=en>Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study</title>
<creator>Mattei, Francesca</creator>
<creator>Liverani, Silvia</creator>
<creator>Guida, Florence</creator>
<creator>Matrat, Mireille</creator>
<creator>Cenée, Sylvie</creator>
<creator>Azizi, Lamiae</creator>
<creator>Menvielle, Gwenn</creator>
<creator>Sanchez, Marie</creator>
<creator>Pilorget, Corinne</creator>
<creator>Lapôtre-Ledoux, Bénédicte</creator>
<creator>Luce, Danièle</creator>
<creator>Richardson, Sylvia</creator>
<creator>Stücker, Isabelle</creator>
<contributor>Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) - Université Paris-Sud - Paris 11 (UP11) - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Paul Brousse - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institute of Public Health - University of Cambridge, Royaume Uni ; </contributor>
<contributor>Imperial College London</contributor>
<contributor>Epidémiologie environnementale des cancers ; Université Paris-Sud - Paris 11 (UP11) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Sydney School of Public Health ; The University of Sydney [Sydney]</contributor>
<contributor>Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE) ; Université Claude Bernard Lyon 1 (UCBL) - Institut National de Recherche sur les Transports et leur Sécurité (INRETS) - Institut de Veille Sanitaire (INVS)</contributor>
<contributor>Registre du Cancer de la Somme ; CHU Amiens-Picardie</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This analysis was supported by La Fondation ARC pour la Recherche surle Cancer. The ICARE study was funded by the French National Research Agency(ANR); French National Cancer Institute (INCA); French Agency for Food,Environmental and Occupational Health and Safety (ANSES); French Institute forPublic Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); LaFondation de France; Ministry of Labour (Direction Générale du Travail); Ministry ofHealth (Direction Générale de la Santé).</contributor>
<description>International audience</description>
<source>ISSN: 1351-0711</source>
<source>Occupational and Environmental Medicine</source>
<publisher>BMJ Publishing Group</publisher>
<identifier>hal-01282444</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282444</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282444</source>
<source>Occupational and Environmental Medicine, BMJ Publishing Group, 2016, 73 (6), pp.368-377. 〈10.1136/oemed-2015-103177〉</source>
<identifier>DOI : 10.1136/oemed-2015-103177</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1136/oemed-2015-103177</relation>
<identifier>PUBMED : 26911986</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26911986</relation>
<language>en</language>
<subject lang=en> Lung cancer</subject>
<subject lang=en> Occupational exposure</subject>
<subject lang=en> Organic solvents</subject>
<subject lang=en>Bayesian profile regression</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances. OBJECTIVES: The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos. METHODS: We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case-control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression. RESULTS: After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters. CONCLUSIONS: Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk</description>
<date>2016-02</date>
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