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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers</title>
<creator>Gueguen, Yannick</creator>
<creator>Saulnier, Denis</creator>
<creator>Santini, Adrien</creator>
<creator>Magré, Kevin</creator>
<creator>Garen, Pierre</creator>
<creator>Bernagout, Solène</creator>
<creator>Nohl, Marine</creator>
<creator>Bouisset, Patrick</creator>
<creator>Helme, Herehia</creator>
<creator>Planes, Serge</creator>
<creator>Le Moullac, Gilles</creator>
<contributor>Interactions Hôtes-Pathogènes-Environnements (IHPE) ; Université de Perpignan Via Domitia (UPVD) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Ecosystèmes Insulaires Océaniens (UMR 241) (EIO) ; Institut de Recherche pour le Développement (IRD) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Institut Louis Malardé [Papeete] (ILM) ; Institut de Recherche pour le Développement (IRD) - Université de la Polynésie Française (UPF)</contributor>
<contributor>LESE Laboratoire d'Etude et de Suivi de l'Environnement ; Institut de Radioprotection et de Sûreté Nucléaire (IRSN)</contributor>
<contributor>Laboratoire d'Excellence CORAIL (LabEX CORAIL) ; Institut de Recherche pour le Développement (IRD) - Université des Antilles et de la Guyane (UAG) - École des hautes études en sciences sociales (EHESS) - École pratique des hautes études (EPHE) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Université de la Réunion (UR) - Université de la Polynésie Française (UPF) - Université de Nouvelle Calédonie - Institut d'écologie et environnement</contributor>
<description>International audience</description>
<source>. Marine Pollution Bulletin</source>
<identifier>hal-01526382</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01526382</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01526382</source>
<source>. Marine Pollution Bulletin, 2017, 118 (1-2), pp.420-426. 〈http://www.sciencedirect.com.inee.bib.cnrs.fr/science/article/pii/S0025326X17302187〉. 〈10.1016/j.marpolbul.2017.03.012〉</source>
<identifier>DOI : 10.1016/j.marpolbul.2017.03.012</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.marpolbul.2017.03.012</relation>
<identifier>PUBMED : 28320509</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28320509</relation>
<source>http://www.sciencedirect.com.inee.bib.cnrs.fr/science/article/pii/S0025326X17302187</source>
<language>en</language>
<subject lang=en> Pinctada margaritifera</subject>
<subject lang=en> French Polynesia</subject>
<subject lang=en> Cadmium</subject>
<subject lang=en> Chromium</subject>
<subject lang=en> Gene expression</subject>
<subject lang=en> Metallothionein</subject>
<subject>[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>This study was designed to identify in the pearl oyster Pinctada margaritifera, used as a bio-accumulator, molecular biomarkers for the presence of heavy metals in the lagoon environment. Pearl oysters were exposed to 2 concentrations (1 and 10 μg L− 1) of cadmium (Cd) and chromium (Cr) compared to a control. Twelve target genes encoding proteins potentially involved in the response to heavy metal contamination with antioxidant, detoxification or apoptosis activities were selected. P. margaritifera accumulated Cd but not Cr, and mortality was related to the amount of Cd accumulated in tissues. In response to Cd-Cr contamination, metallothionein (MT) was significantly up-regulated by Cd-Cr at both concentrations, while 7 others (SOD, CAT, GPX, GSTO, GSTM, CASP, MDR) were down-regulated. Based on the development of these molecular tools, we propose that the pearl oyster, P. margaritifera, could be used as a sentinel species for heavy metal contamination in the lagoons of tropical ecosystems.</description>
<date>2017-03-18</date>
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