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<title lang=en>A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors</title>
<creator>Michel, Denis</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>This manuscript is an extended version, including an updated bibliography, of the article: Hierarchical cooperativity mediated by chromatin remodeling; the model of the MMTV transcription regulation. Michel, D. 2011. J. Theor. Biol. 287, 74-81</description>
<description>International audience</description>
<source>ISSN: 0022-5193</source>
<source>EISSN: 1095-8541</source>
<source>Journal of Theoretical Biology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01211233</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211233</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211233/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211233/file/nucleosome.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01211233</source>
<source>Journal of Theoretical Biology, Elsevier, 2011, 〈10.1016/j.jtbi.2011.07.020〉</source>
<identifier>ARXIV : 1509.07440</identifier>
<relation>info:eu-repo/semantics/altIdentifier/arxiv/1509.07440</relation>
<identifier>DOI : 10.1016/j.jtbi.2011.07.020</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2011.07.020</relation>
<language>en</language>
<subject lang=en>Chromatin remodeling</subject>
<subject lang=en>cooperativity</subject>
<subject lang=en>transcription factor</subject>
<subject lang=en>MMTV</subject>
<subject lang=en>glucocorticoid receptor</subject>
<subject lang=en>non-equilibrium</subject>
<subject>[SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their importance in gene expression remains unclear. Although the influence of nucleosome position on the regulation of gene expression is generally envisioned under the quasi-equilibrium perspective, it is proposed that given the ATP-dependence of chro-matin remodeling enzymes, certain mechanisms necessitate non-equilibrium treatments. Examination of the celebrated chromatin remodeling system of the mouse mammary tumor virus, in which the binding of transcription factors opens the way to other ones, reveals that breaking equilibrium offers a subtle mode of transcription factor cooperativity, avoids molecular trapping phenomena and allows to reconcile previously conflicting experimental data. This mechanism provides a control lever of promoter responsiveness to transcription factor combinations, challenging the classical view of the unilateral influence of pioneer on secondary transcription factors.</description>
<date>2011</date>
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