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<publisher>HAL CCSD</publisher>
<title lang=en>Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss)</title>
<creator>Cottin, V.</creator>
<creator>Bel, E.</creator>
<creator>Bottero, P.</creator>
<creator>Dalhoff, K.</creator>
<creator>Humbert, M.</creator>
<creator>Lazor, R.</creator>
<creator>Sinico, R.A.</creator>
<creator>Sivasothy, P.</creator>
<creator>Wechsler, M.E.</creator>
<creator>Groh, M.</creator>
<creator>Marchand-Adam, S.</creator>
<creator>Khouatra, C.</creator>
<creator>Wallaert, B.</creator>
<creator>Taillé, C.</creator>
<creator>Delaval, P.</creator>
<creator>Cadranel, J.</creator>
<creator>Bonniaud, P.</creator>
<creator>Prévot, G.</creator>
<creator>Hirschi, S.</creator>
<creator>Gondouin, A.</creator>
<creator>Dunogué, B.</creator>
<creator>Chatté, G.</creator>
<creator>Briault, A.</creator>
<creator>Jayne, D.</creator>
<creator>Guillevin, L.</creator>
<creator>Cordier, J.-F.</creator>
<contributor>Centre de Référence des Maladies Pulmonaires Rares [bron] ; Hôpital Louis Pradel [Lyon]</contributor>
<contributor>Department of Pneumology [Lyon] ; Hospices Civils de Lyon</contributor>
<contributor>Academic Medical Center [Amsterdam] (AMC) ; University of Amsterdam [Amsterdam] (UvA)</contributor>
<contributor>Universität zu Lübeck [Lübeck]</contributor>
<contributor>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</contributor>
<contributor>Université de Lausanne (UNIL)</contributor>
<contributor>Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital</contributor>
<contributor>University of Colorado Health Sciences Center and National Jewish Medical and Research Center</contributor>
<contributor>Pathologies Respiratoires : Protéolyse et Aérosolthérapie ; Université François Rabelais - Tours - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de Pneumologie et Immuno-Allergologie ; Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de pneumologie et réanimation [CHU Tenon] ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Tenon [APHP]</contributor>
<contributor>Theranoscan ; Université Pierre et Marie Curie - Paris 6 (UPMC)</contributor>
<contributor>Lipides - Nutrition - Cancer (U866) (LNC) ; Université de Bourgogne (UB) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service des maladies respiratoires [CHU de Dijon] ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)</contributor>
<contributor>Université Claude Bernard Lyon 1 (UCBL)</contributor>
<contributor>Hôpital Louis-Pradel [Lyon] ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon - Hôpital Louis-Pradel</contributor>
<description>IF 8.332 </description>
<description>International audience</description>
<source>ISSN: 0903-1936</source>
<source>EISSN: 1399-3003</source>
<source>European Respiratory Journal</source>
<publisher>European Respiratory Society</publisher>
<identifier>hal-01406073</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406073</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406073</source>
<source>European Respiratory Journal, European Respiratory Society, 2016, 48 (5), pp.1429--1441. 〈10.1183/13993003.00097-2016〉</source>
<identifier>DOI : 10.1183/13993003.00097-2016</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1183/13993003.00097-2016</relation>
<identifier>PUBMED : 27587545</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27587545</relation>
<language>en</language>
<subject lang=en>Management</subject>
<subject lang=en>Nomenclature</subject>
<subject lang=en>Vasculitides</subject>
<subject lang=en>asthma</subject>
<subject lang=en>Granulomatosis</subject>
<subject lang=en>Consensus conference</subject>
<subject lang=en>Term-follow-up</subject>
<subject lang=en>Cohort</subject>
<subject lang=en>Antineutrophil cytoplasmic antibodies</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail. In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease. The study population included 157 patients (mean±SD age 49.4±14.1 years), with a mean±SD blood eosinophil count of 7.4±6.4×109 L-1 at diagnosis. There was a mean±SD of 11.8±18.2 years from the onset of asthma to the diagnosis of EGPA, of 1.4±8.4 years from the first onset of peripheral eosinophilia to the diagnosis of EGPA, and of 7.4±6.4 years from EGPA diagnosis to the final visit. Despite inhaled and oral corticosteroid treatment, the severity of asthma increased 3-6 months before the onset of the systemic manifestations. Asthma was severe in 57%, 48%, and 56% of patients at diagnosis, at 3 years, and at the final visit, respectively. Persistent airflow obstruction was present in 38%, 30%, and 46% at diagnosis, at 3 years, and at the final visit, respectively. In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long-term management and morbidity. Copyright © 2016 ERS.</description>
<date>2016</date>
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