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<identifier>oai:HAL:hal-01668334v1</identifier>
<datestamp>2017-12-22</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>The role of blood rheology in sickle cell disease</title>
<creator>Connes, Philippe</creator>
<creator>Alexy, Tamas</creator>
<creator>Detterich, Jon</creator>
<creator>Romana, Marc</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Ballas, Samir K.</creator>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 0268-960X</source>
<source>Blood Reviews</source>
<publisher>Elsevier</publisher>
<identifier>hal-01668334</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668334</identifier>
<source>https://hal.univ-antilles.fr/hal-01668334</source>
<source>Blood Reviews, Elsevier, 2016, 30 (2), pp.111 - 118. 〈10.1016/j.blre.2015.08.005〉</source>
<identifier>DOI : 10.1016/j.blre.2015.08.005</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.blre.2015.08.005</relation>
<language>en</language>
<subject lang=en>Blood viscosity</subject>
<subject lang=en> Red blood cell aggregation</subject>
<subject lang=en> Red blood cell deformability</subject>
<subject lang=en> Sickle cell disease</subject>
<subject lang=en> Vaso-occlusive crises</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellular modulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives.</description>
<date>2016-03</date>
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