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<datestamp>2018-01-11</datestamp>
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<title lang=en>Revisiting previously iInvestigated plants: A molecular networking based study of Geissospermum laeve</title>
<creator>Ramos, Alexander E. Fox</creator>
<creator>Alcover, Charlotte</creator>
<creator>Evanno, Laurent</creator>
<creator>Maciuk, Alexandre</creator>
<creator>Litaudon, Marc</creator>
<creator>Duplais, Christophe</creator>
<creator>Bernadat, Guillaume</creator>
<creator>Gallard, Jean-Francois</creator>
<creator>Jullian, Jean-Christophe</creator>
<creator>Mouray, Elisabeth</creator>
<creator>Grellier, Philippe</creator>
<creator>Loiseau, Philippe M.</creator>
<creator>Pomel, Sébastien</creator>
<creator>Poupon, Erwan</creator>
<creator>Champy, Pierre</creator>
<creator>Beniddir, Mehdi A.</creator>
<contributor>Équipe “Pharmacognosie-Chimie des Substances Naturelles” BioCIS ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Université Paris Sud (Paris 11)</contributor>
<contributor>Université Paris-Saclay</contributor>
<contributor>UPR 2301 Institut de Chimie des Substances Naturelles (ICSN) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Ecologie des forêts de Guyane (ECOFOG) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut National de la Recherche Agronomique (INRA) - Université des Antilles et de la Guyane (UAG) - AgroParisTech - Université de Guyane (UG) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Équipe “Molécules Fluorées et Chimie Médicinale” BioCIS ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>UMR 7245 Unité Molécules de Communication et Adaptation des Microorganismes (MCAM) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Sorbonne Universités</contributor>
<contributor>Muséum National d’Histoire Naturelle (MNHN)</contributor>
<contributor>Équipe “Chimiothérapie Antiparasitaire” BioCIS ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Cienciactiva, an initiative of the National Council for Science, Technology and Technological Innovation (CONCYTEC) [239-2015-FONDECYT]; French ANR [ANR-15-CE29-0001]</contributor>
<source>ISSN: 0163-3864</source>
<source>EISSN: 1520-6025</source>
<source>Journal of Natural Products</source>
<publisher>American Chemical Society</publisher>
<identifier>hal-01605065</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01605065</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01605065</source>
<source>Journal of Natural Products, American Chemical Society, 2017, 80 (4), pp.1007-1014. 〈10.1021/acs.jnatprod.6b01013〉</source>
<identifier>DOI : 10.1021/acs.jnatprod.6b01013</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jnatprod.6b01013</relation>
<identifier>PRODINRA : 402605</identifier>
<identifier>PUBMED : 28282127</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28282127</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Three new monoterpene indole alkaloids (13) have been isolated from the bark of Geissospermum laeve-, together with the known alkaloids (-)-leuconolam (4), geissolosimine (5), and geissospermine (6). The structures of 1-3 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of geissolaevine (I). was deduced from the comparison of experimental and theoretically calculated ECD spectra. The isolation workflow was guided by a molecular networking-based dereplication strategy using an in-house database of monoterpene indole alkaloids. In addition, five known compounds previously undescribed in the Geissospermum genus were dereplicated from the G. laeve alkaloid extract network and were assigned with various levels of identification confidence. The antiparasitic activities against Plasmodium falciparum and Leishmania donovani as well as the Ortotoxic activity against the MRC-5 cell line were determined for compounds 1-5.</description>
<date>2017</date>
</dc>
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