untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:17:46Z</responseDate>
<request identifier=oai:HAL:hal-01668336v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01668336v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-PARIS7</setSpec>
<setSpec>collection:DSIMB</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UNIV-REUNION</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Rheology of red blood cells in patients with HbC disease</title>
<creator>Lemonne, Nathalie</creator>
<creator>Billaud, Marie</creator>
<creator>Waltz, Xavier</creator>
<creator>Romana, Marc</creator>
<creator>Hierso, Régine</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB) ; Université Bordeaux Segalen - Bordeaux 2 - CHU Bordeaux [Bordeaux] - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<description>International audience</description>
<source>ISSN: 1386-0291</source>
<source>Clinical Hemorheology and Microcirculation</source>
<publisher>IOS Press</publisher>
<identifier>hal-01668336</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668336</identifier>
<source>https://hal.univ-antilles.fr/hal-01668336</source>
<source>Clinical Hemorheology and Microcirculation, IOS Press, 2016, 61 (4), pp.571 - 577. 〈10.3233/CH-141906〉</source>
<identifier>DOI : 10.3233/CH-141906</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-141906</relation>
<language>en</language>
<subject lang=en>HbC disease</subject>
<subject lang=en> blood viscosity</subject>
<subject lang=en> red blood cell deformability</subject>
<subject lang=en> sickle cell disease</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Patients with hemoglobin C disease (CC) usually do not develop severe complications in comparison with individuals with sickle cell anemia (SS) or with sickle cell hemoglobin C disease (SC). The present study compared the hematological, biochemical, hemorheological and clinical characteristics of CC patients to those of SS, SC and healthy individuals (AA). Blood viscosity was measured at 225 s(-1) with a cone plate viscometer. The hematocrit-to-blood viscosity ratio (HVR), i.e. an index of red blood cell (RBC) oxygen transport effectiveness, was calculated. RBC deformability was determined at 30 Pa by ektacytometry, and RBC aggregation properties by syllectometry. CC and SC had higher blood viscosity and lower HVR than AA. Nevertheless, HVR was higher in CC compared to SS and tended to be higher than in SC. The CC group exhibited very rigid hyperchromic RBC compared to the three other groups. RBC aggregation abnormalities were observed in CC: low RBC aggregation index and high RBC aggregates strength. Despite these hemorheological abnormalities, CC never had hospitalized painful vaso-occlusive crisis or acute chest syndrome. In contrast, all of them had splenomegaly. Of note, 2 out of 7 CC developed retinopathy or otologic disorders. Whether the blood hyperviscosity and decreased RBC deformability are responsible for these complications is unknown. The higher oxygen transport effectiveness (i.e., HVR) of CC compared to SS is probably at the origin of the very low risk of medical complication in this population.</description>
<date>2016-01-14</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
