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<identifier>oai:HAL:hal-00384337v1</identifier>
<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)</title>
<creator>Bertani, Stephane</creator>
<creator>Houel, Emeline</creator>
<creator>Stien, Didier</creator>
<creator>Chevolot, Lionel</creator>
<creator>Jullian, Valérie</creator>
<creator>Garavito, Giovanni</creator>
<creator>Bourdy, Genevieve</creator>
<creator>Deharo, Eric</creator>
<contributor>laboratoire de parasitologie comparée et modèles expérimentaux</contributor>
<contributor>Ecologie des forêts de Guyane (ECOFOG) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut National de la Recherche Agronomique (INRA) - Université des Antilles et de la Guyane (UAG) - AgroParisTech - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>UPS CNRS Guyane (UCG) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Pharmacochimie des substances naturelles et pharmacophores redox ; Université Paul Sabatier - Toulouse 3 (UPS)</contributor>
<contributor>Departamento de farmacia, Facultad de ciencas ; Universidad nacional de Colombie</contributor>
<contributor>faculte des sciences pharmaceutiques (umr 152 IRD) ; Faculte des Sciences Pharmaceutiques</contributor>
<description>International audience</description>
<source>ISSN: 0378-8741</source>
<source>Journal of Ethnopharmacology</source>
<publisher>Elsevier</publisher>
<identifier>hal-00384337</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00384337</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00384337</source>
<source>Journal of Ethnopharmacology, Elsevier, 2007, 108, pp.155-157. 〈10.1016/j.jep.2006.04.017〉</source>
<identifier>DOI : 10.1016/j.jep.2006.04.017</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2006.04.017</relation>
<language>en</language>
<subject lang=it>Antimalarial</subject>
<subject lang=it>Quassia amara</subject>
<subject lang=it>Quassinoids</subject>
<subject lang=it>Simalikalactone D</subject>
<subject lang=it>Traditional medicine</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea.</description>
<date>2007-04</date>
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