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<title lang=en>Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America.</title>
<creator>Morisset, Stéphane</creator>
<creator>Peyron, François</creator>
<creator>Lobry, Jean R</creator>
<creator>Garweg, Justus</creator>
<creator>Ferrandiz, Josette</creator>
<creator>Musset, Karine</creator>
<creator>Gomez-Marin, Jorge Enrique</creator>
<creator>De La Torre, Alejandra</creator>
<creator>Demar, Magalie</creator>
<creator>Carme, Bernard</creator>
<creator>Mercier, Corinne</creator>
<creator>Garin, Jean François</creator>
<creator>Cesbron-Delauw, Marie-France</creator>
<contributor>Laboratoire de Biométrie et Biologie Evolutive (LBBE) ; Université Claude Bernard Lyon 1 (UCBL) - Institut National de Recherche en Informatique et en Automatique (Inria) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Laboratoire de Parasitologie et Pathologie exotique ; Université Claude Bernard Lyon 1 (UCBL)</contributor>
<contributor>Service de Parasitologie et Pathologie exotique ; Hospices Civils de Lyon</contributor>
<contributor>Clinic for Inflammatory Eye Disease ; Swiss Eye Institute</contributor>
<contributor>Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM) ; Université Joseph Fourier - Grenoble 1 (UJF) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Grupo de Estudio en Parasitologia Molecular (GEPAMOL) ; Universidad del Quindio</contributor>
<contributor>Unité de Maladies infectieuses et tropicales-Hygiène hospitalière (EA 3593) ; Centre Hospitalier Andrée Rosemon</contributor>
<contributor>Epidemiologie des Parasitoses Tropicales (EPaT Team) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Laboratoire de Parasitologie-Mycologie ; Université Paris Diderot - Paris 7 (UPD7)</contributor>
<source>ISSN: 1286-4579</source>
<source>Microbes and Infection</source>
<publisher>Elsevier</publisher>
<identifier>hal-00306841</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00306841</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00306841</source>
<source>Microbes and Infection, Elsevier, 2008, 10 (7), pp.742-7. 〈10.1016/j.micinf.2008.04.001〉</source>
<identifier>DOI : 10.1016/j.micinf.2008.04.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.micinf.2008.04.001</relation>
<identifier>PUBMED : 18539501</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/18539501</relation>
<language>en</language>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.</description>
<date>2008-06</date>
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