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<title lang=en>Specific Proteomic Response of Unio pictorum Mussel to a Mixture of Glyphosate and Microcystin-LR.</title>
<creator>Malécot, Mélodie</creator>
<creator>Guével, Blandine</creator>
<creator>Pineau, Charles</creator>
<creator>Holbech, Bente Frost</creator>
<creator>Bormans, Myriam</creator>
<creator>Wiegand, Claudia</creator>
<contributor>Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO) ; Université de Rennes 1 (UR1) - INEE - Observatoire des Sciences de l'Univers de Rennes (OSUR) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Plateforme Protéomique-Biogenouest (PPB) ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Proteomics Core Facility (Protim) ; Université de Rennes 1 (UR1) - Plateforme Génomique Santé Biogenouest® - Plateforme Génomique Santé Biogenouest®</contributor>
<contributor>Biology, Southern Denmark ; UNIVERSITY OF SOUTHERN DENMARK</contributor>
<contributor>Université européenne de Bretagne (UEB)</contributor>
<contributor>European University of Brittany (UEB), Rennes, France</contributor>
<description>International audience</description>
<source>ISSN: 1535-3893</source>
<source>EISSN: 1535-3907</source>
<source>Journal of Proteome Research</source>
<publisher>American Chemical Society</publisher>
<identifier>hal-00877711</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00877711</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00877711</source>
<source>Journal of Proteome Research, American Chemical Society, 2013, 12 (11), pp.5281-5292. 〈10.1021/pr4006316〉</source>
<identifier>DOI : 10.1021/pr4006316</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1021/pr4006316</relation>
<identifier>PUBMED : 23972258</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23972258</relation>
<language>en</language>
<subject lang=en>DIGE</subject>
<subject lang=en>cyanobacteria</subject>
<subject lang=en>Roundup</subject>
<subject lang=en>proteomics</subject>
<subject lang=en>bivalve</subject>
<subject lang=en>Unionid</subject>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Cyanobacterial toxins and pesticides regularly impact freshwaters. Microcystin-LR is one of the most toxic and common cyanobacterial toxins whereas glyphosate is the active ingredient of a widely use herbicide. As filter feeders, freshwater mussels are particularly exposed. Like many native bivalve species, Unio pictorum suffers from a continuous decline in Europe. In order to get a deeper insight of its response to contaminants, U. pictorum was exposed to either 10 μg L(-1) of microcystin-LR or 10 μg L(-1) of glyphosate or a mixture of both. Proteins of the digestive glands were extracted and analyzed by DIGE. Gel analysis revealed 103 spots with statistical variations, and the response seems to be less toward glyphosate than to microcystin-LR. Specific spots have variations only when exposed to the mixture, showing that there is an interaction of both contaminants in the responses triggered. The proteins of 30 spots have been identified. They belong mostly to the cytoskeleton family, but proteins of the oxidative pathway, detoxification, and energetic metabolism were affected either by glyphosate or microcystin-LR or by the mixture. These results demonstrate the importance to study contaminants at low concentrations representative of those found in the field and that multicontaminations can lead to different response pathways.</description>
<date>2013-09-09</date>
</dc>
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