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<publisher>HAL CCSD</publisher>
<title lang=en>Severe hematologic complications after lung transplantation in patients with telomerase complex mutations</title>
<creator>Borie, Raphael</creator>
<creator>Kannengiesser, Caroline</creator>
<creator>Hirschi, Sandrine</creator>
<creator>Le Pavec, Jérôme</creator>
<creator>Mal, Hervé</creator>
<creator>Bergot, Emmanuel</creator>
<creator>Jouneau, Stéphane</creator>
<creator>Naccache, Jean-Marc</creator>
<creator>Revy, Patrick</creator>
<creator>Boutboul, David</creator>
<creator>Tour, Régis, </creator>
<creator>Wemeau-Stervinou, Lidwine</creator>
<creator>Philit, Francois</creator>
<creator>Cordier, Jean-François</creator>
<creator>Thabut, Gabriel</creator>
<creator>Crestani, Bruno</creator>
<creator>Cottin, Vincent</creator>
<contributor>Service de Pneumologie A ; Hôpital Bichat - Claude Bernard [Paris] - Centre de compétence des maladies pulmonaires rares</contributor>
<contributor>Centre de recherche sur l'Inflammation (CRI) ; Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Service de pneumologie (Strasbourg) ; CHU Strasbourg - Nouvel Hôpital Civil</contributor>
<contributor>Service de chirurgie thoracique et transplantation pulmonaire ; Centre chirurgical Marie Lannelongue</contributor>
<contributor>Service de pneumologie B ; Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Bichat - Claude Bernard [Paris] - Université Paris Diderot - Paris 7 (UPD7)</contributor>
<contributor>Service de Pneumologie ; CHU Caen</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de pneumologie. Centre de compétence des maladies pulmonaires rares ; CHU Tenon [APHP]</contributor>
<contributor>Laboratory of Genome Dynamics in the Immune System ; Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service d'Immunopathologie [Hôpital Saint-Louis, Paris] ; Université Paris Diderot - Paris 7 (UPD7) - CHU Saint Louis [APHP]</contributor>
<contributor>Service d'Hématologie Greffe ; Hospital Saint Louis</contributor>
<contributor>Service de pneumologie. Centre de compétence des maladies pulmonaires rares ; Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>Centre de Référence des Maladies Pulmonaires Rares [bron] ; Hôpital Louis Pradel [Lyon]</contributor>
<contributor>Hôpital Louis-Pradel [Lyon] ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon - Hôpital Louis-Pradel</contributor>
<contributor>Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques ; Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire ; Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de pneumologie A ; Assistance publique - Hôpitaux de Paris (AP-HP) - Université Paris Diderot - Paris 7 (UPD7) - Hôpital Bichat</contributor>
<contributor>Département Hospitalo-universtaire FIRE (Fibrosis, Inflammation and Remodeling) ; LabEx Inflamex</contributor>
<contributor>Department of Pneumology [Lyon] ; Hospices Civils de Lyon</contributor>
<description>International audience</description>
<source>ISSN: 1053-2498</source>
<source>The Journal of Heart and Lung Transplantation</source>
<publisher>Elsevier</publisher>
<identifier>hal-01146848</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848/file/Severe%20hematological%20complications%20after%20lung%20transplantation_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848</source>
<source>The Journal of Heart and Lung Transplantation, Elsevier, 2015, 34 (4), pp.538--546. 〈10.1016/j.healun.2014.11.010〉</source>
<identifier>DOI : 10.1016/j.healun.2014.11.010</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.healun.2014.11.010</relation>
<identifier>PUBMED : 25612863</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25612863</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Mutations in the telomerase complex (TERT and TR) are associated with pulmonary fibrosis and frequent hematologic manifestations. The aim of this study was to characterize the prognosis of lung transplantation in patients with TERT or TR mutations. METHODS: Patients with documented TERT or TR mutations who received a lung transplant between 2007 and 2013 in France were identified via an exhaustive search of the lung transplantation network, one expert genetic laboratory, and the clinical research network on rare pulmonary diseases. RESULTS: There were 9 patients (7 men) with TERT (n = 6) or TR (n = 3) mutations who received a single (n = 8) or a double (n = 1) lung transplant for pulmonary fibrosis. Median age was 50 years (range, 35-61 years) at diagnosis and 52 years (range, 37-62 years) at the time of lung transplantation. Thrombocytopenia was present in 7 patients before lung transplantation. After lung transplantation, 6 patients developed myelodysplasia and/or bone marrow failure, directly contributing to death in 4 cases. Anemia was observed in 9 patients, and neutropenia was observed in 3 patients. The median survival after lung transplantation was 214 days (range, 59-1,709 days). CONCLUSIONS: Patients with mutations of the telomerase complex are at high risk of severe hematologic complications after lung transplantation, in particular, bone marrow failure. Specific recommendations should be developed for appropriate guidance regarding hematologic risk assessment before transplantation and management of the post-transplantation immunosuppressive regimen.</description>
<date>2015</date>
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