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<identifier>oai:HAL:inserm-00128119v1</identifier>
<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Spectrin-based skeleton in red blood cells and malaria.</title>
<creator>Dhermy, Didier</creator>
<creator>Schrével, Joseph</creator>
<creator>Lecomte, Marie-Christine</creator>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Molécules de Communication et Adaptation des Micro-Organismes (MCAM) ; Muséum National d'Histoire Naturelle (MNHN) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<source>ISSN: 1065-6251</source>
<source>Current Opinion in Hematology</source>
<publisher>Lippincott, Williams & Wilkins</publisher>
<identifier>inserm-00128119</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00128119</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00128119/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00128119/file/Dhermy_et_al_figures.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00128119</source>
<source>Current Opinion in Hematology, Lippincott, Williams & Wilkins, 2007, 14 (3), pp.198-202. 〈10.1097/MOH.0b013e3280d21afd〉</source>
<identifier>DOI : 10.1097/MOH.0b013e3280d21afd</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/MOH.0b013e3280d21afd</relation>
<identifier>PUBMED : 17414207</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/17414207</relation>
<language>en</language>
<subject lang=en>malaria</subject>
<subject lang=en>spectrin</subject>
<subject lang=en>hereditary elliptocytosis</subject>
<subject>[SDV.BC] Life Sciences [q-bio]/Cellular Biology</subject>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<subject>[SDV.GEN] Life Sciences [q-bio]/Genetics</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>PURPOSE OF REVIEW: Malaria represents one of the most important selective factors affecting human populations. Several inherited diseases of red blood cells lead to resistance at the erythrocytic stage. Among patients who experience hereditary elliptocytosis related to mutations of erythrocyte membrane proteins, molecular studies have shown the prevalence of particular spectrin mutations in patients from black ethnic extraction, leading one to question the selection of new malaria-resistant genes. RECENT FINDINGS: Prospective epidemiological and molecular studies in West Africa have confirmed the prevalence (between 0.6 and 1.6%) of particular spectrin mutations related to hereditary elliptocytosis. These studies have also revealed the frequency of alpha-spectrin chain polymorphisms, associated in cis with elliptocytogenic spectrin mutations and defining particular spectrin allele haplotypes. Culture studies of Plasmodium falciparum in elliptocytes bearing such elliptocytogenic alleles of spectrin showed that these alleles are supplementary genetic factors of malaria resistance in vitro. SUMMARY: Certain instances of spectrin mutations or polymorphisms have not yet been shown to constitute new factors of innate resistance to malaria in vivo. Epidemiological surveys of hereditary elliptocytosis and parasite culture studies, however, have argued that the relationships between parasite and spectrin-based skeleton should be examined more closely and the molecular interactions between parasite ligands and particular spectrin chain domains should be characterized.</description>
<date>2007-05</date>
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