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<title lang=en>Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish</title>
<creator>Pellegrini, E.</creator>
<creator>Diotel, Nicolas</creator>
<creator>Vaillant-Capitaine, C.</creator>
<creator>Pérez Maria, R.</creator>
<creator>Gueguen, M.-M.</creator>
<creator>Nasri, A.</creator>
<creator>Cano Nicolau, J.</creator>
<creator>KAH, O.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI) ; Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor> Laboratorio de Ictiología ; Instituto Nacional de Limnología (INALI)</contributor>
<contributor>Laboratoire de Biosurveillance de l'Environnement (LBE) ; Faculté des Sciences de Bizerte</contributor>
<contributor>The ANR PROOF (CES-2008-11), the Post-Grenelle grant NEMO and the TC2N Program supported this research.</contributor>
<description>International audience</description>
<source>ISSN: 0960-0760</source>
<source>Journal of Steroid Biochemistry and Molecular Biology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01174214</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174214</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174214/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174214/file/Steroid%20modulation%20of%20neurogenesis.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01174214</source>
<source>Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2016, 160, pp.27-36. 〈10.1016/j.jsbmb.2015.06.011〉</source>
<identifier>DOI : 10.1016/j.jsbmb.2015.06.011</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2015.06.011</relation>
<identifier>PUBMED : 26151741</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26151741</relation>
<language>en</language>
<subject lang=en>Zebrafish</subject>
<subject lang=en>Aromatase</subject>
<subject lang=en>Endocrine Disruptors</subject>
<subject lang=en>Estradiol</subject>
<subject lang=en>Neurosteroids</subject>
<subject lang=en>Radial glial progenitor cells</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Estrogens are known as steroid hormones affecting the brain in many different ways and a wealth of data now document effects on neurogenesis. Estrogens are provided by the periphery but can also be locally produced within the brain itself due to local aromatization of circulating androgens. Adult neurogenesis is described in all vertebrate species examined so far, but comparative investigations have brought to light differences between vertebrate groups. In teleost fishes, the neurogenic activity is spectacular and adult stem cells maintain their mitogenic activity in many proliferative areas within the brain. Fish are also quite unique because brain aromatase expression is limited to radial glia cells, the progenitor cells of adult fish brain. The zebrafish has emerged as an interesting vertebrate model to elucidate the cellular and molecular mechanisms of adult neurogenesis, and notably its modulation by steroids. The main objective of this review is to summarize data related to the functional link between estrogens production in the brain and neurogenesis in fish. First, we will demonstrate that the brain of zebrafish is an endogenous source of steroids and is directly targeted by local and/or peripheral steroids. Then, we will present data demonstrating the progenitor nature of radial glial cells in the brain of adult fish. Next, we will emphasize the role of estrogens in constitutive neurogenesis and its potential contribution to the regenerative neurogenesis. Finally, the negative impacts on neurogenesis of synthetic hormones used in contraceptive pills production and released in the aquatic environment will be discussed</description>
<date>2016</date>
<contributor>ANR-CES-2008-011, ANR-CES-2008-011</contributor>
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