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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Serum sex steroids measured in middle-aged European and African-Caribbean men by gas chromatography-mass spectrometry.</title>
<creator>Giton, Frank</creator>
<creator>Fiet, Jean</creator>
<creator>Cornu, Jean-Nicolas</creator>
<creator>Cussenot, Olivier</creator>
<creator>Bélanger, Alain</creator>
<creator>Urien, Saîk</creator>
<creator>Oliva, Alejandro</creator>
<creator>Blanchet, Pascal</creator>
<creator>Multigner, Luc</creator>
<contributor>Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)</contributor>
<contributor>Laboratory of molecular endocrinology and oncology ; CR-CHUQ</contributor>
<contributor>Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM) ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service d'urologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre</contributor>
<description>International audience</description>
<source>ISSN: 0804-4643</source>
<source>EISSN: 1479-683X</source>
<source>European Journal of Endocrinology</source>
<publisher>BioScientifica</publisher>
<identifier>hal-00876034</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00876034</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00876034</source>
<source>European Journal of Endocrinology, BioScientifica, 2011, 165 (6), pp.917-24. 〈10.1530/EJE-11-0551〉</source>
<identifier>DOI : 10.1530/EJE-11-0551</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1530/EJE-11-0551</relation>
<identifier>PUBMED : 21951700</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/21951700</relation>
<language>en</language>
<subject>[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European men. DESIGN AND METHODS: Serum steroid hormone levels were determined in men participating in a systematic public health study funded by the French National Health Insurance system. Blood was collected in the morning from 304 healthy African-Caribbean and European men aged between 40 and 69 years. Serum steroids were measured by mass spectrometry-gas chromatography, except for DHEAS and sex hormone-binding globulin, which were determined by RIA. Data were analyzed in 10-year age intervals by analysis of covariance, with adjustment for age, body mass index, waist-to-hip ratio, tobacco and alcohol consumption, and season of sampling. RESULTS: Compared with Europeans, African-Caribbean men presented significantly higher serum levels of measured bioavailable testosterone, 4-androstenedione (4-dione), and estrone (E1) regardless of the age group, of 5-androstenediol (5-diol) in those aged 40-49 and 50-59 years, and of testosterone (TT) and dihydrotestosterone in those aged 40-49 years. In contrast, European men aged 40-69 years showed significantly higher serum levels of DHEA and DHEAS. CONCLUSIONS: Significant differences in serum steroid hormone levels were observed in middle-aged African-Caribbean and European men. Whether such differences could contribute to ethnic differences in disease risk in adult men remains to be investigated. Some steroids, such as bioavailable TT, 4-dione, 5-diol, and E1, deserve particular attention.</description>
<date>2011-12</date>
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