untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:06:25Z</responseDate>
<request identifier=oai:HAL:hal-01526434v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01526434v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:MARQUIS</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:HL</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET-CCII</setSpec>
<setSpec>collection:IRSET-SMS</setSpec>
<setSpec>collection:IRSET-HIAEC</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:FNCLCC</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:OSS</setSpec>
<setSpec>collection:IRSET-1</setSpec>
<setSpec>collection:IRSET-3</setSpec>
<setSpec>collection:IRSET-2</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:IRSET-EHESP</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:INSERM</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Soluble CD14 acts as a DAMP in human macrophages: origin and involvement in inflammatory cytokine/chemokine production</title>
<creator>LEVEQUE, Manuella</creator>
<creator>Simonin-Le Jeune, Karin</creator>
<creator>Jouneau, Stéphane</creator>
<creator>Moulis, Solenn</creator>
<creator>Desrues, Benoit</creator>
<creator>Belleguic, Chantal</creator>
<creator>Brinchault, Graziella</creator>
<creator>Le Trionnaire, Sophie</creator>
<creator>Gangneux, Jean-Pierre</creator>
<creator>Dimanche-Boitrel, Marie-Thérèse</creator>
<creator>Martin-Chouly, Corinne</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Chemistry, Oncogenesis, Stress and Signaling (COSS) ; Université de Rennes 1 (UR1) - CRLCC Eugène Marquis (CRLCC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Centre de Ressource et de Compétences de la Mucoviscidose ; Université de Rennes 1 (UR1) - CHU Pontchaillou [Rennes]</contributor>
<description>International audience</description>
<source>ISSN: 0892-6638</source>
<source>EISSN: 1530-6860</source>
<source>FASEB Journal</source>
<publisher>Federation of American Society of Experimental Biology</publisher>
<identifier>hal-01526434</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434/file/Soluble%20CD14%20acts%20as%20a%20DAMP%20in%20human-accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01526434</source>
<source>FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (5), pp.1891-1902. 〈10.1096/fj.201600772R〉</source>
<identifier>PUBMED : 28122919</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28122919</relation>
<identifier>DOI : 10.1096/fj.201600772R</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1096/fj.201600772R</relation>
<language>en</language>
<subject lang=en>Cystic fibrosis</subject>
<subject lang=en> inflammasome</subject>
<subject lang=en> Inflammation</subject>
<subject lang=en> NF-κB</subject>
<subject>[SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The innate immune system is able to detect bacterial LPS through the pattern recognition receptor CD14, which delivers LPS to various TLR signaling complexes that subsequently induce intracellular proinflammatory signaling cascades. In a previous study, we showed the overproduction of the soluble form of CD14 (sCD14) by macrophages from patients with cystic fibrosis (CF). CF is an autosomal recessive disorder that is caused by mutations in the gene that encodes the CFTR protein and is characterized by persistent inflammation. Macrophages play a significant role in the initial stages of this disease due to their inability to act as suppressor cells, leading to chronic inflammation in CF. In this work, we investigated the origin of sCD14 by human macrophages and studied the effect of sCD14 on the production of inflammatory cytokine/chemokine. Our data indicate that sCD14 stimulate proinflammatory cytokine/chemokine production in a manner that is independent of LPS but dependent on the TLR-4/CD14 membrane complex, NF-κB, and the inflammasome. Therefore, sCD14, overproduced by CF macrophages, originates primarily from the endocytosis/exocytosis process and should be considered to be a danger-associated molecular pattern. This elucidation of the origin and inflammation-induced mechanisms associated with sCD14 contributes to our understanding of maintained tissue inflammation.</description>
<date>2017</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
