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<datestamp>2017-12-21</datestamp>
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<title lang=en>Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.</title>
<creator>Garlantézec, Ronan</creator>
<creator>Warembourg, Charline</creator>
<creator>Monfort, Christine</creator>
<creator>Labat, Laurence</creator>
<creator>Pulkkinen, Juha</creator>
<creator>Multigner, Luc</creator>
<creator>Bonvallot, Nathalie</creator>
<creator>Chevrier, Cécile</creator>
<creator>Cordier, Sylvaine</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire de Toxicologie et Génopathies ; Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>Laboratory of Chemistry ; University of Eastern Finland</contributor>
<description>International audience</description>
<source>ISSN: 0091-6765</source>
<source>EISSN: 1552-9924</source>
<source>Environmental Health Perspectives</source>
<publisher>National Institute of Environmental Health Sciences</publisher>
<identifier>hal-00866023</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00866023</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00866023/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00866023/file/Urinary_Glycol_Ether-accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00866023</source>
<source>Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2013, 121 (10), pp.1167-73. 〈10.1289/ehp.1206103〉</source>
<identifier>DOI : 10.1289/ehp.1206103</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1289/ehp.1206103</relation>
<identifier>PUBMED : 23838187</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23838187</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. OBJECTIVE: To study the relation between women's exposure to glycol ethers and time to pregnancy. METHODS: Urine from randomly selected women in the PELAGIE mother-child cohort who had samples collected before 19 weeks of gestation was tested to measure eight glycol ether metabolites by chromatography coupled to mass spectrometry. Time to pregnancy was collected at the beginning of the pregnancy by asking women how many months they took to conceive. Associations between metabolite levels and time to pregnancy were estimated in 519 women with complete data using discrete-time Cox proportional hazards models to adjust for potential confounders. RESULTS: Glycol ether metabolites were detected in 6% (for ethoxyacetic acid) to 93% (for phenoxyacetic and butoxyacetic acids) of urine samples. Phenoxyacetic acid was the only metabolite with a statistically significant association with longer time to pregnancy (fecundability OR 0.82; 95% CI: 0.63, 1.06 for the second and third quartile combined; fecundability OR 0.70; 95% CI: 0.52, 0.95 for a fourth-quartile (≥1.38 mg/L) vs. first-quartile concentration (<0.14 mg/L)). This association remained stable after multiple sensitivity analyses. CONCLUSION: Phenoxyacetic acid, which was present in most of the urine samples tested in our study, was associated with increased time to pregnancy. This metabolite and its main parent compound, 2-phenoxyethanol, are plausible causes of decreased fecundability, but may also be surrogates for potential co-exposures frequently present in cosmetics.</description>
<date>2013-07-09</date>
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