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<datestamp>2017-12-21</datestamp>
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<title lang=en>Frequency of pain crises in sickle cell anemia and its relationshipwith the sympatho-vagal balance, blood viscosity and inflammation</title>
<creator>Nebor, Danitza </creator>
<creator>Bowers, Andre</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Knight-Madden, Jennifer</creator>
<creator>Romana, Marc</creator>
<creator>Reid, Harvey</creator>
<creator>Barthélémy, Jean-Claude</creator>
<creator>Cumming , Vanessa</creator>
<creator>Hue, Olivier</creator>
<creator>Elion, Jacques</creator>
<creator>Reid, Marvin</creator>
<creator>Connes, Philippe</creator>
<contributor>Inserm U763, Pointe-à-Pitre, Guadeloupe; Université des Antilles et de la Guyane ; Inserm U763, Pointe-à-Pitre, Guadeloupe; Université des Antilles et de la Guyane</contributor>
<contributor>Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences ; Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences</contributor>
<contributor>Sickle Cell Unit, Tropical Medicine Research Institute ; Sickle Cell Unit, Tropical Medicine Research Institute</contributor>
<contributor>Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS) ; Université Jean Monnet [Saint-Étienne] (UJM) - Centre Hospitalier Universitaire de Saint-Etienne</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<description>International audience</description>
<source>ISSN: 0390-6078</source>
<source>EISSN: 1592-8721</source>
<source>Haematologica</source>
<publisher>Ferrata Storti Foundation</publisher>
<identifier>hal-01163973</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01163973</identifier>
<source>https://hal.univ-antilles.fr/hal-01163973</source>
<source>Haematologica, Ferrata Storti Foundation, 2011, 96 (11), pp.1589-1594. 〈10.3324/haematol.2011.047365〉</source>
<identifier>DOI : 10.3324/haematol.2011.047365</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3324/haematol.2011.047365</relation>
<language>en</language>
<subject lang=en>sickle cell anemia</subject>
<subject lang=en>autonomic function</subject>
<subject lang=en>inflammation</subject>
<subject lang=en>hemoglobin</subject>
<subject lang=en>blood viscosity</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BackgroundRecent evidence suggests that autonomic nervous system activity could be involved in thepathophysiology of sickle cell disease, but it is unclear whether differences in autonomic nervoussystem activity are detectable during steady state in patients with mild and severe disease.The aim of the present study was to compare the autonomic nervous system activity, bloodrheology, and inflammation in patients with sickle cell anemia according to the frequency ofacute pain crisis.Design and MethodsTwenty-four healthy volunteers, 20 patients with sickle cell anemia with milder disease, and15 patients with sickle cell anemia with more severe disease were recruited. Milder disease wasdefined as having no pain crisis within the previous year. More severe disease was defined ashaving had within the previous year three or more pain crises which were documented by aphysician and required treatment with narcotics. The autonomic nervous system activity wasdetermined by spectral analysis of nocturnal heart rate variability. Blood viscosity determinationand measurements of several inflammatory markers (interleukin-6, soluble vascular celladhesion molecule-1, soluble CD40 ligand and sL-selectin) were made on blood samples collectedin steady-state conditions.ResultsResults showed that: 1) patients who had suffered more frequent pain crises had lowerparasympathetic activity and greater sympatho-vagal imbalance than both controls andpatients with milder disease. However, when adjusted for age, no significant difference wasdetected between the two sickle cell anemia patient groups; 2) patients who had suffered morefrequent pain crises had higher blood viscosity than patients with milder disease, and this wasnot dependent on age.ConclusionsResults from the present study indicate that both the autonomic nervous system activity andblood viscosity are impaired in patients with sickle cell anemia exhibiting high frequency ofpain crisis in comparison with those who did not experience a crisis within the previous year.</description>
<date>2011</date>
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