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<publisher>HAL CCSD</publisher>
<title lang=en>Factors associated with poor outcomes among adults hospitalised for influenza in France: A three-year prospective multicenter study</title>
<creator>Loubet, Paul</creator>
<creator>Samih-Lenzi, Nezha</creator>
<creator>Galtier, Florence</creator>
<creator>Vanhems, Philippe</creator>
<creator>Loulergue, Pierre</creator>
<creator>Duval, Xavier</creator>
<creator>Jouneau, Stéphane</creator>
<creator>Postil, Déborah</creator>
<creator>Rogez, Sylvie</creator>
<creator>Valette, Martine</creator>
<creator>Merle, Corinne</creator>
<creator>Régis, Corinne</creator>
<creator>Costa, Yolande</creator>
<creator>Lesieur, Zineb</creator>
<creator>Tattevin, Pierre</creator>
<creator>Lina, Bruno</creator>
<creator>Carrat, Fabrice</creator>
<creator>Launay, Odile</creator>
<contributor>Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service des Maladies Infectieuses ; CHU Cochin [AP-HP]</contributor>
<contributor>CIC Cochin Pasteur (CIC 1417) ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP] - Hôtel-Dieu - Université Paris Descartes - Paris 5 (UPD5) - Groupe hospitalier Broca - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)</contributor>
<contributor>CIC Montpellier ; Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Hôpital Saint Eloi</contributor>
<contributor>CHU Saint-Eloi</contributor>
<contributor>Service d'Hygiène, Epidémiologie et Prévention [Lyon] ; Hôpital Edouard Herriot</contributor>
<contributor>Centre International de Recherche en Infectiologie (CIRI) ; École normale supérieure - Lyon (ENS Lyon) - Université Claude Bernard Lyon 1 (UCBL) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Infection, Antimicrobiens, Modélisation, Evolution (IAME) ; Université Paris Diderot - Paris 7 (UPD7) - Université Paris 13 (UP13) - Université Sorbonne Paris Cité (USPC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CIC Hôpital Bichat ; Institut National de la Santé et de la Recherche Médicale (INSERM) - UFR de Médecine - AP-HP Hôpital Bichat - Claude-Bernard (Paris) </contributor>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de Bactériologie, Virologie, Hygiène [CHU Limoges] ; CHU Limoges</contributor>
<contributor>Centre National de Référence Virus Influenza (Région Sud) ; Hospices Civils de Lyon</contributor>
<contributor>Laboratoire de Biométrie et Biologie Evolutive (LBBE) ; Université Claude Bernard Lyon 1 (UCBL) - Institut National de Recherche en Informatique et en Automatique (Inria) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service des maladies infectieuses et réanimation médicale ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou</contributor>
<contributor>Fonction, structure et inactivation d'ARN bactériens ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>French National Enterovirus/Parechovirus Reference centre ; Hospices Civils de Lyon</contributor>
<contributor>Département de santé publique ; CHU Saint-Antoine [APHP]</contributor>
<contributor>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Recherche Agronomique (INRA) - Université Sorbonne Paris Cité (USPC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>The study sites received funding from Sanofi Pasteur and Sanofi Pasteur MSD for the FLUVAC study. Vaccine producers had no role in the study design, data analysis, decision to publish or preparation of the manuscript.</contributor>
<description>International audience</description>
<source>ISSN: 1386-6532</source>
<source>Journal of Clinical Virology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01302409</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/file/Factors%20associated%20with%20poor%20outcomes.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409</source>
<source>Journal of Clinical Virology, Elsevier, 2016, 79, pp.68-73. 〈10.1016/j.jcv.2016.04.005〉</source>
<identifier>DOI : 10.1016/j.jcv.2016.04.005</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2016.04.005</relation>
<identifier>PUBMED : 27105315</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27105315</relation>
<language>en</language>
<subject lang=en> Hospitalisation</subject>
<subject lang=en> Influenza</subject>
<subject lang=en> Severe</subject>
<subject lang=en> Vaccination</subject>
<subject lang=en>Adults</subject>
<subject lang=en> Antiviral</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<subject>[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Background: Influenza is an important cause of serious illness and death, particularly in elderly and high-risk groups. Objectives Aim of this study was to identify factors associated with poor outcomes among adults hospitalized in France for laboratory-confirmed seasonal influenza. Study design Patients hospitalized for influenza were identified in a prospective, multicenter study carried out in French hospitals during three consecutive influenza seasons (2012–2015). Influenza virus infection was confirmed by reverse transcription polymerase chain reaction. Sociodemographic and clinical variables were compared according to the virus type and subtype. Risk factors for complications, intensive care unit (ICU) admission and death were analyzed by backward stepwise logistic regression. Results The study population consisted of 566 patients, of whom 56% were older than 65 years and 82% had underlying chronic illnesses. Type A influenza viruses infected 422 patients (75%), including subtype H3N2 in 239 patients (57%). The prior vaccine coverage rate was 38%. Complications occurred in 255 patients (45%), consisting mainly of pneumonia (n = 143, 30%) and respiratory failure (n = 116, 20%). Eighty-three patients (15%) were admitted to an ICU, and the in-hospital mortality rate was 4% (n = 21). Sixty-six patients (12%) received oseltamivir. Age over 65 years was the only identified risk factor for complications. Risk factors for ICU admission were an absence of vaccination, no oseltamivir administration before admission, pre-existing chronic respiratory disease, and current smoking. Age over 65 years and ICU admission were risk factors for death. Conclusions Older individuals and patients with underlying conditions are most at risk of influenza complications. Vaccination and early oseltamivir administration, both of which are recommended for these patients, appear to reduce ICU admissions</description>
<date>2016</date>
</dc>
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