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<title lang=en>Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis.</title>
<creator>Butali, Azeez</creator>
<creator>Little, Julian</creator>
<creator>Chevrier, Cécile</creator>
<creator>Cordier, Sylvian</creator>
<creator>Steegers-Theunissen, Régine P. M.</creator>
<creator>Jugessur, Astanand</creator>
<creator>Oladugba, Bola</creator>
<creator>Mossey, Peter A</creator>
<contributor>Epidemiology and Community Medicine ; University of Ottawa</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Department of Obstetrics and Gynaecology, Erasmus MC ; University Medical Centre Rotterdam</contributor>
<contributor>Department of Epidemiology ; Erasmus MC Rotterdam</contributor>
<description>International audience</description>
<source>ISSN: 1542-0752</source>
<source>EISSN: 1542-0760</source>
<source>Birth Defects Research Part A: Clinical and Molecular Teratology</source>
<publisher>Wiley</publisher>
<identifier>hal-00875899</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875899</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875899</source>
<source>Birth Defects Research Part A: Clinical and Molecular Teratology, Wiley, 2013, 97 (8), pp.509-14. 〈10.1002/bdra.23133〉</source>
<identifier>DOI : 10.1002/bdra.23133</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.23133</relation>
<identifier>PUBMED : 23670871</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23670871</relation>
<language>en</language>
<subject lang=en>cleft lip and palate</subject>
<subject lang=en>MTHFR</subject>
<subject lang=en>folic acid</subject>
<subject lang=en>individual patient data</subject>
<subject lang=en>pooled-analysis</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analytical approach on four studies that used similar methods. METHODS: We used logistic regression to analyze the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non-syndromic cleft palate (CP)] and control groups. RESULTS: There was a reduced risk of CL(P) with maternal folic acid use (p = 0.008; OR = 0.70, 95% CI: 0.65-0.94) and with supplements containing folic acid (p = 0.028, OR = 0.80, 95% CI: 0.65-0.94). Maternal smoking increased the risk of both CL(P) (p < 10 e-3; OR = 1.62, 95% CI: 1.35-1.95) and CP (p = 0.028; OR = 1.38, 95% CI: 1.04-1.83). No significant risk was observed with either maternal or fetal MTHFR C677T genotypes. CONCLUSION: This individual participant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.</description>
<date>2013-08</date>
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