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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>The HLA-G low expressor genotype is associated with protection against bipolar disorder.</title>
<creator>Debnath, Monojit</creator>
<creator>Busson, Marc</creator>
<creator>Jamain, Stéphane</creator>
<creator>Etain, Bruno</creator>
<creator>Hamdani, Nora</creator>
<creator>Moins-Teisserenc, Hélène</creator>
<creator>Boukouaci, Wahid</creator>
<creator>Lajnef, Mohamed</creator>
<creator>Bengoufa, Djaouida</creator>
<creator>Malafosse, Alain</creator>
<creator>Bellivier, Frank</creator>
<creator>Henry, Chantal</creator>
<creator>Kahn, Jean-Pierre</creator>
<creator>Krishnamoorthy, Rajagopal</creator>
<creator>Charron, Dominique</creator>
<creator>Leboyer, Marion</creator>
<creator>TAmouza, Ryad</creator>
<contributor>Hématologie -Immunologie -Cibles thérapeutiques ; Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)</contributor>
<contributor>Laboratoire Jean Dausset ; Assistance publique - Hôpitaux de Paris (AP-HP) - Groupe Hospitalier Saint-Louis-Lariboisière- Fernand-Widal</contributor>
<contributor>Service de Psychiatrie ; Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)</contributor>
<contributor>Pôle de Psychiatrie [Créteil] ; Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor</contributor>
<contributor>Fondation FondaMental ; Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor</contributor>
<contributor>Département de Psychiatrie ; Université de Genève (UNIGE)</contributor>
<contributor>Service de Psychiatrie et Psychologie Clinique ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) - Hôpital Jeanne-d'Arc</contributor>
<contributor>Pharmacogénétique et abords thérapeutiques des maladies héréditaires ; Université des Antilles et de la Guyane (UAG) - Université Paris Diderot - Paris 7 (UPD7) - IFR2 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>This work was supported by INSERM (UMRS 940 and U955), Assistance Publique des Hôpitaux de Paris, Agence Nationale pour la Recherche (ANR MNP2008 -VIP-Project), and the GIS NERF (grant to Monojit Debnath), Réseau Thématique de Recherche et de Soins en Santé Mentale (Fondation FondaMental®).</contributor>
<description>International audience</description>
<source>ISSN: 0198-8859</source>
<source>Human Immunology</source>
<publisher>Elsevier</publisher>
<identifier>inserm-00864639</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00864639</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00864639/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00864639/file/HLA-G_and_BD_manuscript_-1.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00864639</source>
<source>Human Immunology, Elsevier, 2013, 74 (5), pp.593-7. 〈10.1016/j.humimm.2012.11.032〉</source>
<identifier>DOI : 10.1016/j.humimm.2012.11.032</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2012.11.032</relation>
<identifier>PUBMED : 23246584</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23246584</relation>
<language>en</language>
<subject lang=en>Bipolar disorders</subject>
<subject lang=en>HLA-G</subject>
<subject lang=en>Polymorphism Immune modulation</subject>
<subject lang=en>Seasonality of birth</subject>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.</description>
<date>2013-05</date>
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