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<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd> <responseDate>2018-01-17T12:03:05Z</responseDate> <request identifier=oai:HAL:hal-01632553v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request> <GetRecord> <record> <header> <identifier>oai:HAL:hal-01632553v1</identifier> <datestamp>2018-01-11</datestamp> <setSpec>type:ART</setSpec> <setSpec>subject:sdv</setSpec> <setSpec>collection:UNIV-RENNES1</setSpec> <setSpec>collection:CNRS</setSpec> <setSpec>collection:UNIV-AG</setSpec> <setSpec>collection:UNIV-ANGERS</setSpec> <setSpec>collection:METIS-EHESP</setSpec> <setSpec>collection:MARQUIS</setSpec> <setSpec>collection:IGDR</setSpec> <setSpec>collection:IRSET</setSpec> <setSpec>collection:HL</setSpec> <setSpec>collection:IGDR-GFI</setSpec> <setSpec>collection:IFR140</setSpec> <setSpec>collection:FNCLCC</setSpec> <setSpec>collection:BIOSIT</setSpec> <setSpec>collection:UR1-HAL</setSpec> <setSpec>collection:UR1-SDV</setSpec> <setSpec>collection:IRSET-8</setSpec> <setSpec>collection:STATS-UR1</setSpec> <setSpec>collection:UR1-UFR-SVE</setSpec> <setSpec>collection:EHESP</setSpec> <setSpec>collection:INSERM</setSpec> <setSpec>collection:USPC</setSpec> </header> <metadata><dc> <publisher>HAL CCSD</publisher> <title lang=en>Hilar fat infiltration: A new prognostic factor in metastatic clear cell renal cell carcinoma with first-line sunitinib treatment</title> <creator>Kammerer-Jacquet, Solene-Florence</creator> <creator>Brunot, Angélique</creator> <creator>Bensalah, Karim</creator> <creator>Campillo-Gimenez, Boris</creator> <creator>Lefort, Mathilde</creator> <creator>Bayat, Sahar</creator> <creator>Ravaud, Alain</creator> <creator>Dupuis, Frantz</creator> <creator>Yacoub, Mokrane</creator> <creator>Verhoest, Gregory</creator> <creator>Peyronnet, Benoit</creator> <creator>Mathieu, Romain</creator> <creator>Lespagnol, Alexandra</creator> <creator>Mosser, Jean</creator> <creator>Edeline, Julien</creator> <creator>Laguerre, Brigitte</creator> <creator>Bernhard, Jean-Christophe</creator> <creator>Rioux-Leclercq, Nathalie</creator> <contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>Université de Rennes 1 (UR1)</contributor> <contributor>CRLCC Eugène Marquis (CRLCC)</contributor> <contributor>Service d'urologie ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor> <contributor>Modélisation Conceptuelle des Connaissances Biomédicales ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>Département Méthodes quantitatives en santé publique (METIS) ; École des Hautes Études en Santé Publique [EHESP] (EHESP)</contributor> <contributor>Hôpital Saint-André ; CHU Bordeaux [Bordeaux] - Hôpital Saint -André</contributor> <contributor>CHU de Bordeaux Pellegrin [Bordeaux]</contributor> <contributor>Transcriptional networks in gametogenesis and cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>CHU Pontchaillou [Rennes]</contributor> <contributor>Plate-forme transcriptome ; Université de Rennes 1 (UR1) - IFR140</contributor> <contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS)</contributor> <contributor>Centre Eugène Marquis (CRLCC )</contributor> <contributor>Service d'urologie, andrologie et transplantation rénale ; Université Bordeaux Segalen - Bordeaux 2 - CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin</contributor> <contributor>The authors would like to thank the Ligue Contre le Cancer, CORECT, Rennes Hospital and the French Institute of Cancer (INCa) for their financial support.</contributor> <description>International audience</description> <source>ISSN: 1078-1439</source> <source>Urologic Oncology: Seminars and Original Investigations</source> <publisher>Elsevier</publisher> <identifier>hal-01632553</identifier> <identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553</identifier> <identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553/document</identifier> <identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553/file/Hilar%20fat%20infiltration_accepted.pdf</identifier> <source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01632553</source> <source>Urologic Oncology: Seminars and Original Investigations, Elsevier, 2017, 35 (10), pp.603.e7 - 603.e14. 〈10.1016/j.urolonc.2017.05.015〉</source> <identifier>DOI : 10.1016/j.urolonc.2017.05.015</identifier> <relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.urolonc.2017.05.015</relation> <identifier>PUBMED : 28619630</identifier> <relation>info:eu-repo/semantics/altIdentifier/pmid/28619630</relation> <language>en</language> <subject lang=en>Clear cell renal cell carcinoma</subject> <subject lang=en>Sunitinib</subject> <subject lang=en>Prognostic</subject> <subject lang=en>Hilar fat infiltration</subject> <subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject> <subject>[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology</subject> <type>info:eu-repo/semantics/article</type> <type>Journal articles</type> <description lang=en>Introduction: The selection of patients with metastatic clear cell renal cell carcinoma (ccRCC) who may benefit from targeted tyrosine kinase inhibitors has been a challenge, even more so now with the advent of new therapies. Hilar fat infiltration (HFI) is a validated prognostic factor in nonmetastatic ccRCC (TNM 2009 staging system) but has never been studied in metastatic patients. We aimed to assess its phenotype and prognostic effect in patients with metastatic ccRCC treated with first-line sunitinib.Materials and methods: In a multicentric study, we retrospectively included 90 patients and studied the corresponding ccRCC at the pathological, immunohistochemical, and molecular levels. Patient and tumor characteristics were compared using univariate and multivariate analysis. All the features were then studied by Cox models for prognostic effect.Results: HFI was found in 42 patients (46.7%), who had worse prognosis (Heng criteria) (P = 0.003), liver metastases (P = 0.036), and progressive diseases at first radiological evaluation (P = 0.024). The corresponding ccRCC was associated with poor pathological prognostic factors that are well known in nonmetastatic ccRCC. For these patients, median progression-free survival was 4 months vs. 13 months (P = 0.02), and median overall survival was 14 months vs. 29 months (P = 0.006). In a multivariate Cox model integrating all the variables, only poor prognosis, according to the Heng criteria and HFI, remained independently associated with both progression-free survival and overall survival.Conclusion: HFI was demonstrated for the first time to be an independent poor prognostic factor. Its potential role in predicting resistance to antiangiogenic therapy warrants further investigation.</description> <date>2017</date> </dc> </metadata> </record> </GetRecord> </OAI-PMH>