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<datestamp>2018-01-11</datestamp>
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<title lang=en>High-Fat Diet-Induced IL-17A Exacerbates Psoriasiform Dermatitis in a Mouse Model of Steatohepatitis</title>
<creator>Morel, Franck</creator>
<creator>Silvain, Christine</creator>
<creator>Lecron, Jean-Claude</creator>
<creator>Vasseur, Philippe</creator>
<creator>Serres, Laura</creator>
<creator>Jegou, Jean-Francois</creator>
<creator>Pohin, Mathilde</creator>
<creator>Delwail, Adriana</creator>
<creator>Petit-Paris, Isabelle</creator>
<creator>Levillain, Pierre</creator>
<creator>Favot, Laure</creator>
<creator>Samson, Michel</creator>
<creator>Yssel, Hans</creator>
<contributor>Laboratoire des Arts et Métiers ParisTech d'Angers - Procédés Matériaux Durabilité (LAMPA - PMD)</contributor>
<contributor>Hôpital de la Milétrie ; CHU de Poitiers</contributor>
<contributor>Laboratoire Inflammation, tissus épithéliaux et cytokines (LITEC) ; Université de Poitiers</contributor>
<contributor>Pharmacologie des anti-infectieux ; Université de Poitiers - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Laboratoire d'Anatomo-Pathologie ; CHU de Poiters</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Centre d'Immunologie et de Maladies Infectieuses (CIMI) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>University of Poitiers</contributor>
<contributor> Poitiers University Hospital</contributor>
<contributor> Nord Deux-Sevres Hospital</contributor>
<contributor> Region Poitou-Charentes</contributor>
<description>International audience</description>
<source>ISSN: 0002-9440</source>
<source>EISSN: 1525-2191</source>
<source>American Journal of Pathology</source>
<publisher>American Society for Investigative Pathology</publisher>
<identifier>hal-01390977</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977</source>
<source>American Journal of Pathology, American Society for Investigative Pathology, 2016, 186 (9), pp.2292--2301. 〈10.1016/j.ajpath.2016.05.012〉</source>
<identifier>DOI : 10.1016/j.ajpath.2016.05.012</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ajpath.2016.05.012</relation>
<identifier>PUBMED : 27423696</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27423696</relation>
<language>en</language>
<subject lang=en>innate lymphoid-cells</subject>
<subject lang=en> liver-disease</subject>
<subject lang=en> skin inflammation</subject>
<subject lang=en> risk</subject>
<subject lang=en> mice</subject>
<subject lang=en> cytokines</subject>
<subject lang=en> il-22</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.</description>
<date>2016</date>
</dc>
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