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<title lang=en>Human testis steroidogenesis is inhibited by phthalates.</title>
<creator>Desdoits-Lethimonier, Christele</creator>
<creator>Albert, Océane</creator>
<creator>Le Bizec, Bruno</creator>
<creator>Perdu, E.</creator>
<creator>Zalko, D.</creator>
<creator>Courant, F.</creator>
<creator>Lesné, Laurianne</creator>
<creator>Guille, François</creator>
<creator>Dejucq-Rainsford, Nathalie</creator>
<creator>Jégou, Bernard</creator>
<contributor>Environnement viral et chimique & reproduction ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>LABERCA ; ONIRIS</contributor>
<contributor>ToxAlim (ToxAlim) ; Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse</contributor>
<contributor>CRLCC Eugène Marquis (CRLCC)</contributor>
<description>International audience</description>
<source>ISSN: 0268-1161</source>
<source>EISSN: 1460-2350</source>
<source>Human Reproduction</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-00876965</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00876965</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00876965</source>
<source>Human Reproduction, Oxford University Press (OUP), 2012, 27 (5), pp.1451-9. 〈10.1093/humrep/des069〉</source>
<identifier>DOI : 10.1093/humrep/des069</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/des069</relation>
<identifier>PUBMED : 22402212</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22402212</relation>
<language>en</language>
<subject lang=en>human testis</subject>
<subject lang=en>testosterone</subject>
<subject lang=en>phthalates</subject>
<subject lang=en>endocrine disruption</subject>
<subject lang=en>steroidogenesis</subject>
<subject>[SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular testosterone production in the rat. However, the scarce and contradictory data concerning humans have cast doubt over whether these compounds are also anti-androgenic in man. We therefore investigated the direct effects of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) on organo-cultured adult human testis and a human cell line. METHODS: Adult human testis explants or NCI-H295R adrenocortical human cells were cultured with DEHP or MEHP. The effects of ketoconazole, used as a reference molecule, were also assessed. RESULTS: In both models, DEHP and MEHP significantly inhibited testosterone production. The effects of both phthalates appeared to be specific for steroidogenesis, as INSL3 production by Leydig cells was not altered. Furthermore, the phthalates of interest had no effect on inhibin B production by Sertoli cells or on germ cell apoptosis. As only a small fraction of the phthalates added was found in the testis explants, and as these compounds were found to be metabolized, we estimate that the anti-androgenic effects observed occurred at concentrations of phthalates that are of the same order of magnitude as exposures reported in the literature for men. CONCLUSIONS: We provide the first evidence that DEHP and MEHP can inhibit testosterone production in the adult human testis. This is consistent with recent epidemiological findings of an inverse correlation between exposure to MEHP and testosterone concentrations.</description>
<date>2012-05</date>
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