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<title lang=en>The ancestral gene repertoire of animal stem cells</title>
<creator>Alie, Alexandre</creator>
<creator>Hayashi, Tetsutaro</creator>
<creator>Sugimura, Itsuro</creator>
<creator>Manuel, Michael</creator>
<creator>Sugano, Wakana</creator>
<creator>Mano, Akira</creator>
<creator>Satoh, Nori</creator>
<creator>Agata, Kiyokazu</creator>
<creator>Funayama, Noriko</creator>
<contributor>Phylogénie, Anatomie, Evolution (PAE) ; Systématique, adaptation, évolution (SAE) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Evolution Paris Seine ; Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Precursory Research for Embryonic Science and Technology (PREST) program of the Japan Science and Technology Agency</contributor>
<contributor> Japan Society for Promotion of Science Long-Term Postdoctoral Fellowship Program</contributor>
<contributor> Ministry of Education, Culture, Sports, Science and Technology of Japan</contributor>
<description>International audience</description>
<source>ISSN: 0027-8424</source>
<source>EISSN: 1091-6490</source>
<source>Proceedings of the National Academy of Sciences of the United States of America </source>
<publisher>National Academy of Sciences</publisher>
<identifier>hal-01544480</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01544480</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01544480</source>
<source>Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (51), pp.E7093-E7100. 〈10.1073/pnas.1514789112〉</source>
<identifier>DOI : 10.1073/pnas.1514789112</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1514789112</relation>
<language>en</language>
<subject lang=en>Porifera</subject>
<subject lang=en> stem cells</subject>
<subject lang=en> evolution</subject>
<subject lang=en> uPriSCs</subject>
<subject lang=en> RNA binding</subject>
<subject>[SDV.BID] Life Sciences [q-bio]/Biodiversity</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Stem cells are pivotal for development and tissue homeostasis of multicellular animals, and the quest for a gene toolkit associated with the emergence of stem cells in a common ancestor of all metazoans remains a major challenge for evolutionary biology. We reconstructed the conserved gene repertoire of animal stem cells by transcriptomic profiling of totipotent archeocytes in the demosponge Ephydatia fluviatilis and by tracing shared molecular signatures with flatworm and Hydra stem cells. Phylostratigraphy analyses indicated that most of these stem-cell genes predate animal origin, with only few metazoan innovations, notably including several partners of the Piwi machinery known to promote genome stability. The ancestral stem-cell transcriptome is strikingly poor in transcription factors. Instead, it is rich in RNA regulatory actors, including components of the ``germ-line multipotency program'' and many RNA-binding proteins known as critical regulators of mammalian embryonic stem cells.</description>
<date>2015-12</date>
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