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<title lang=en>Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways.</title>
<creator>Kerdivel, Gwenneg</creator>
<creator>Habauzit, Denis</creator>
<creator>Pakdel, Farzad</creator>
<contributor>TREC : Transcription, Environment and Cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Ministère de l'écologie; Programme National de Recherche sur les Perturbateurs endocriniens; INSERM; CNRS; Ligue contre le cancer; IRSET</contributor>
<description>International audience</description>
<source>Int J Endocrinol</source>
<identifier>inserm-00863365</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00863365</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00863365/document</identifier>
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<source>http://www.hal.inserm.fr/inserm-00863365</source>
<source>Int J Endocrinol, 2013, 2013, pp.501851. 〈10.1155/2013/501851〉</source>
<identifier>PUBMED : 23737774</identifier>
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<identifier>DOI : 10.1155/2013/501851</identifier>
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<language>en</language>
<subject>[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel of in vivo and in vitro bioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens.</description>
<date>2013</date>
<rights>info:eu-repo/semantics/OpenAccess</rights>
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