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<title lang=en>Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.</title>
<creator>Solhaug, Anita</creator>
<creator>Holme, Jorn, </creator>
<creator>Haglund, Kaisa</creator>
<creator>Dendele, Béatrice</creator>
<creator>Sergent, Odile</creator>
<creator>Pestka, James, </creator>
<creator>Lagadic-Gossmann, Dominique</creator>
<creator>Eriksen, Gunnar, </creator>
<contributor>Department of Chemistry and Toxicology ; Norwegian Veterinary Institute</contributor>
<contributor>Division of Environmental Medicine ; Norwegian Institute of Public Health</contributor>
<contributor>Department of Biochemistry ; Institute for Cancer Research - The Norwegian Radium Hospital</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Department of Food Science and Human Nutrition ; Michigan State University [East Lansing]</contributor>
<contributor>The work was supported by Research Council of Norway through the project: Toxicological characterization of selected secondary fungal metabolites in Norwegian grain. [Grant nr: 185622/V40].</contributor>
<description>International audience</description>
<source>ISSN: 0378-4274</source>
<source>Toxicology Letters</source>
<publisher>Elsevier</publisher>
<identifier>inserm-00871659</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871659</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871659/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871659/file/Alternariol_induces_abnormal_nuclear_morphology_and_cell_cycle_arrest_in_murine_RAW_264.7_macrophages-accepted.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00871659</source>
<source>Toxicology Letters, Elsevier, 2013, 219 (1), pp.8-17. 〈10.1016/j.toxlet.2013.02.012〉</source>
<identifier>DOI : 10.1016/j.toxlet.2013.02.012</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.toxlet.2013.02.012</relation>
<identifier>PUBMED : 23454835</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23454835</relation>
<language>en</language>
<subject lang=it>Alternariol</subject>
<subject lang=it>Cell cycle</subject>
<subject lang=it>Topoisomerase IIα</subject>
<subject lang=it>Polyploidy</subject>
<subject>[SDV.BC] Life Sciences [q-bio]/Cellular Biology</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The mycotoxin alternariol (AOH), a frequent contaminant in fruit and cereal products, is known to induce DNA damage with subsequent cell cycle arrest. Here we elucidated the effects of AOH on stages of cell cycle progression using the RAW 264.7 macrophage model. AOH resulted in an accumulation of cells in the G2/M-phase (4N). Most cells exhibited a large G2 nucleus whereas numbers of true mitotic cells were reduced relative to control. Both cyclin B1 and p-cdc2 levels increased, while cyclin B1 remained in the cytoplasm; suggesting arrest in the G2/M transition point. Remarkably, after exposure to AOH for 24h, most of the cells exhibited abnormally shaped nuclei, as evidenced by partly divided nuclei, nuclear blebs, polyploidy and micronuclei (MN). AOH treatment also induced abnormal Aurora B bridges, suggesting that cytokinesis was interfered within cells undergoing karyokinesis. A minor part of the resultant G1 tetraploid (4N) cells re-entered the S-phase and progressed to 8N cells.</description>
<date>2013-05-10</date>
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