untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:24:57Z</responseDate>
<request identifier=oai:HAL:hal-01274234v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01274234v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRMAR</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IRSET-TREC</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:IRMAR-AN</setSpec>
<setSpec>collection:CHL</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:UNAM</setSpec>
<setSpec>collection:AGROCAMPUS-OUEST</setSpec>
<setSpec>collection:INRIA</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-MATH-STIC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:IRSET-6</setSpec>
<setSpec>collection:UNIV-RENNES2</setSpec>
<setSpec>collection:UR2-HB</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics</title>
<creator>Michel, Denis</creator>
<creator>Boutin, Benjamin</creator>
<creator>Ruelle, Philippe</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de Recherche Mathématique de Rennes (IRMAR) ; Université de Rennes 1 (UR1) - AGROCAMPUS OUEST - École normale supérieure - Rennes (ENS Rennes) - Institut National de Recherche en Informatique et en Automatique (Inria) - Institut National des Sciences Appliquées (INSA) - Université de Rennes 2 (UR2) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de Recherche en Mathématiques et Physique (UCL IRMP) ; Université Catholique de Louvain (UCL)</contributor>
<description>International audience</description>
<source>ISSN: 0079-6107</source>
<source>Progress in Biophysics and Molecular Biology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01274234</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274234</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274234</source>
<source>Progress in Biophysics and Molecular Biology, Elsevier, 2016, 121 (1), pp.35-44. 〈10.1016/j.pbiomolbio.2016.02.001〉</source>
<identifier>DOI : 10.1016/j.pbiomolbio.2016.02.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbiomolbio.2016.02.001</relation>
<identifier>PUBMED : 26867859</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26867859</relation>
<language>en</language>
<subject lang=en>binding specificity</subject>
<subject lang=en> self-assembly</subject>
<subject lang=en> induced fit</subject>
<subject lang=en> substrate selection</subject>
<subject lang=en> Fluctuation ratchet</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interactions, binding partners are classically envisioned as finely preadapted molecules, selected on the basis of their affinity in one-step associations. But the counterselection of inappropriate interactions can in fact be much more efficiently obtained through difficult multi-step adjustment, whose final high energy state is locked by a fluctuation ratchet. The progressive addition of molecular bonds during stereo-adjustment can be modeled as a predominantly backward random walk whose first arrival is frozen by a micro-irreversible transition. A new criterion of ligand specificity is presented, that is based on the ratio rejection/incorporation. In addition to its role in the selectivity of interactions, this generic recipe can underlie other important biological phenomena such as the regular synthesis at low level of supramolecular complexes, monostable kinetic bimodality, substrate concentration thresholds or the preparation of rapidly depolymerizable structures with stored energy, like microtubules</description>
<date>2016</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
