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<publisher>HAL CCSD</publisher>
<title lang=en>Association between lung cancer somatic mutations and occupational exposure in never-smokers</title>
<creator>Paris, Christophe</creator>
<creator>Do, Pascal</creator>
<creator>Mastroianni, Bénédicte</creator>
<creator>Dixmier, Adrien</creator>
<creator>Dumont, Patrick</creator>
<creator>Pichon, Eric</creator>
<creator>Chouaid, Christos</creator>
<creator>Coudert, Bruno</creator>
<creator>Foucher, Pascal</creator>
<creator>Fraboulet, Séverine</creator>
<creator>Locatelli-Sanchez, Myriam</creator>
<creator>Baize, Nathalie</creator>
<creator>Dansin, Eric</creator>
<creator>Moreau, Lionel</creator>
<creator>Vincent, Michel</creator>
<creator>Missy, Pascale</creator>
<creator>Morin, Franck</creator>
<creator>Moro-Sibilot, Denis</creator>
<creator>Couraud, Sébastien</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Centre François Baclesse</contributor>
<contributor>Hôpital Louis-Pradel [Lyon] ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon - Hôpital Louis-Pradel</contributor>
<contributor>Centre Hospitalier Régional d'Orléans (CHR)</contributor>
<contributor>Institut de biologie de Lille - IBL (IBLI) ; Université de Lille, Sciences et Technologies - Institut Pasteur de Lille - Université de Lille, Droit et Santé - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)</contributor>
<contributor>Service de Pneumologie (CRETEIL - Pneumologie) ; CHI Créteil</contributor>
<contributor>Département d'oncologie médicale [Centre Georges-François Leclerc] ; Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL)</contributor>
<contributor>Service de chirurgie cardio-vasculaire et thoracique (CHU Dijon) ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)</contributor>
<contributor>Hôpital Foch [Suresnes]</contributor>
<contributor>Hospices Civils de Lyon / Centre hospitalier Lyon Sud (HCL) ; Hospices Civils de Lyon</contributor>
<contributor>Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans [UNAM]</contributor>
<contributor>Center Oscar Lambret ; CRLCC Oscar Lambret</contributor>
<contributor>CH Colmar</contributor>
<contributor>INSAVALOR ; Institut National des Sciences Appliquées de Lyon (INSA Lyon)</contributor>
<contributor>Intergroupe Francophone de Cancérologie Thoracique [Paris] (IFCT) ; Intergroupe Francophone de Cancérologie thoracique</contributor>
<contributor> Unité d'Oncologie Thoracique-Pneumologie, CHU de Grenoble, INSERM U823, Grenoble, France. ; Centre Hospitalier Universitaire [Grenoble] (CHU)</contributor>
<description>International audience</description>
<source>European Respiratory Journal</source>
<identifier>hal-01647080</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647080</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647080</source>
<source>European Respiratory Journal, 2017, 50 (4), pp.1700716. 〈10.1183/13993003.00716-2017〉</source>
<identifier>DOI : 10.1183/13993003.00716-2017</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1183/13993003.00716-2017</relation>
<identifier>PUBMED : 29074543</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/29074543</relation>
<language>en</language>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44%, p=0.033), and a higher rate of HER2 mutations (18% versus 4%, p=0.084). ALK alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a BRAF mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced HER2 and PIK3 mutation frequency.Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of EGFR mutations.</description>
<date>2017</date>
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