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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Aggregating exposures & cumulating risk for semivolatile organic compounds: A review</title>
<creator>Pelletier, Maud</creator>
<creator>Bonvallot, Nathalie</creator>
<creator>Glorennec, Philippe</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Maud Pelletier's work was funded with a doctoral grant from the Fondation de France (grant No. 2014-00053331) and the Agence de l’Environnement et de la maîtrise de l’énergie (Ademe) (Grant No. TEZ14-36).</contributor>
<description>International audience</description>
<source>Environmental Research</source>
<identifier>hal-01579608</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579608</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579608</source>
<source>Environmental Research, 2017, 158, pp.649-659. 〈10.1016/j.envres.2017.06.022〉</source>
<identifier>DOI : 10.1016/j.envres.2017.06.022</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2017.06.022</relation>
<identifier>PUBMED : 28732321</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28732321</relation>
<language>en</language>
<subject lang=en>Chemical</subject>
<subject lang=en> Contaminants</subject>
<subject lang=en> Cumulative risk assessment</subject>
<subject lang=en> Environmental Exposure</subject>
<subject lang=en> Environmental Monitoring</subject>
<subject lang=en> Environmental Pollutants</subject>
<subject lang=en> Exposure pathway</subject>
<subject lang=en> health</subject>
<subject lang=en> Humans</subject>
<subject lang=en> mixture</subject>
<subject lang=en> Risk Assessment</subject>
<subject lang=en> Volatile Organic Compounds</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure. Preferential routes and sources of exposure are influenced by SVOC physical-chemical properties such as vapor pressure. The cumulative risk approach for contaminants is based on dose addition. Simple sum of hazard quotient (Hazard Index: HI) is the most commonly used cumulative risk assessment approach, while Relative Potency Factor (RPF) appeared to the best suited - although this calls for a level of toxicological information that limits the number of compounds that can be studied simultaneously. Where both were performed, moving from HI to more refined approach produced similar results. In conclusion, both approaches - exposure aggregation and cumulative risk - rely on simple assumptions. Nevertheless, they allow uncertainty to be reduced, in comparison with source-by-source or chemical-by-chemical approaches.</description>
<date>2017</date>
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