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<title lang=en>The kidney as a reservoir for HIV-1 after renal transplantation.</title>
<creator>Canaud, Guillaume</creator>
<creator>Dejucq-Rainsford, Nathalie</creator>
<creator>Avettand-Fenoël, Véronique</creator>
<creator>Viard, Jean-Paul</creator>
<creator>Anglicheau, Dany</creator>
<creator>Bienaimé, Frank</creator>
<creator>Muorah, Mordi</creator>
<creator>Galmiche, Louise</creator>
<creator>Gribouval, Olivier</creator>
<creator>Noël, Laure-Helene</creator>
<creator>Satie, Anne-Pascale</creator>
<creator>Martinez, Frank</creator>
<creator>Sberro-Soussan, Rebecca</creator>
<creator>Scemla, Anne</creator>
<creator>Gubler, Marie-Claire</creator>
<creator>Friedlander, Gérard</creator>
<creator>Antignac, Corinne</creator>
<creator>Timsit, Marc-Olivier</creator>
<creator>Onetti Muda, Andrea</creator>
<creator>Terzi, Fabiola</creator>
<creator>Rouzioux, Christine</creator>
<creator>Legendre, Christophe</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant ; Université Paris Descartes - Paris 5 (UPD5)</contributor>
<contributor>Néphropathies héréditaires et rein en développement ; Assistance publique - Hôpitaux de Paris (AP-HP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU Necker - Enfants Malades [AP-HP]</contributor>
<contributor>Imagine - Institut des maladies génétiques (IMAGINE - U1163) ; Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato) ; Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)</contributor>
<contributor>Laboratoire de Virologie [CHU Necker] ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Necker - Enfants Malades [AP-HP]</contributor>
<description>International audience</description>
<source>ISSN: 1046-6673</source>
<source>EISSN: 1533-3450</source>
<source>Journal of the American Society of Nephrology</source>
<publisher>American Society of Nephrology</publisher>
<identifier>hal-01121764</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121764</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121764</source>
<source>Journal of the American Society of Nephrology, American Society of Nephrology, 2014, 25 (2), pp.407-19. 〈10.1681/ASN.2013050564〉</source>
<identifier>DOI : 10.1681/ASN.2013050564</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1681/ASN.2013050564</relation>
<identifier>PUBMED : 24309185</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24309185</relation>
<identifier>PUBMEDCENTRAL : PMC3904571</identifier>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Since the recent publication of data showing favorable outcomes for patients with HIV-1 and ESRD, kidney transplantation has become a therapeutic option in this population. However, reports have documented unexplained reduced allograft survival in these patients. We hypothesized that the unrecognized infection of the transplanted kidney by HIV-1 can compromise long-term allograft function. Using electron microscopy and molecular biology, we examined protocol renal transplant biopsies from 19 recipients with HIV-1 who did not have detectable levels of plasma HIV-1 RNA at transplantation. We found that HIV-1 infected the kidney allograft in 68% of these patients. Notably, HIV-1 infection was detected in either podocytes predominately (38% of recipients) or tubular cells only (62% of recipients). Podocyte infection associated with podocyte apoptosis and loss of differentiation markers as well as a faster decline in allograft function compared with tubular cell infection. In allografts with tubular cell infection, epithelial cells of the proximal convoluted tubules frequently contained abnormal mitochondria, and both patients who developed features of subclinical acute cellular rejection had allografts with tubular cell infection. Finally, we provide a novel noninvasive test for determining HIV-1 infection of the kidney allograft by measuring HIV-1 DNA and RNA levels in patients' urine. In conclusion, HIV-1 can infect kidney allografts after transplantation despite undetectable viremia, and this infection might influence graft outcome.</description>
<date>2014-01-31</date>
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