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<title lang=en>Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863</title>
<creator>Mai, Tepoerau</creator>
<creator>Tintillier, F.</creator>
<creator>Lucasson, A.</creator>
<creator>Moriou, C.</creator>
<creator>Bonno, E.</creator>
<creator>Petek, S.</creator>
<creator>Magré, K.</creator>
<creator>Al Mourabit, A.</creator>
<creator>Saulnier, D.</creator>
<creator>Debitus, C.</creator>
<creator>Mai, C.</creator>
<creator>Tintillier, D</creator>
<creator>Lucasson, C</creator>
<creator>Bonno, D</creator>
<creator>Petek, D</creator>
<creator>Magré, C</creator>
<creator>Al Mourabit, C</creator>
<creator>Saulnier, C</creator>
<contributor>Ecosystèmes Insulaires Océaniens (UMR 241) (EIO) ; Institut de Recherche pour le Développement (IRD) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Institut Louis Malardé [Papeete] (ILM) ; Institut de Recherche pour le Développement (IRD) - Université de la Polynésie Française (UPF)</contributor>
<contributor>Institut de Chimie des Substances Naturelles (ICSN) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Centre Océanologique du Pacifique (COP) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)</contributor>
<contributor>Laboratoire d'Excellence CORAIL (LabEX CORAIL) ; Institut de Recherche pour le Développement (IRD) - Université des Antilles et de la Guyane (UAG) - École des hautes études en sciences sociales (EHESS) - École pratique des hautes études (EPHE) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Université de la Réunion (UR) - Université de la Polynésie Française (UPF) - Université de Nouvelle Calédonie - Institut d'écologie et environnement</contributor>
<contributor>Institut de Mécanique et d'Ingénierie de Bordeaux (I2M) ; Institut National de la Recherche Agronomique (INRA) - Université de Bordeaux (UB) - Institut Polytechnique de Bordeaux - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0266-8254</source>
<source>EISSN: 1472-765X</source>
<source>Letters in Applied Microbiology</source>
<publisher>Wiley</publisher>
<identifier>hal-01684926</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01684926</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01684926</source>
<source>Letters in Applied Microbiology, Wiley, 2015, 61 (4), pp.311-317. 〈10.1111/lam.12461〉</source>
<identifier>DOI : 10.1111/lam.12461</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/lam.12461</relation>
<identifier>PUBMED : 26138555</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26138555</relation>
<language>en</language>
<subject lang=en>Leucetta chagosensis</subject>
<subject lang=en>Vibrio harveyi</subject>
<subject lang=en>biofouling</subject>
<subject lang=en>leucettamine</subject>
<subject lang=en>naamidine</subject>
<subject lang=en>naamine</subject>
<subject lang=en>quorum sensing</subject>
<subject lang=en>quorum sensing inhibitors</subject>
<subject lang=en>sponges</subject>
<subject lang=fr>Eponges</subject>
<subject>[SDV.BV] Life Sciences [q-bio]/Vegetal Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known isonaamine A and isonaamidine A. Isonaamidine A and isonaamine D were identified as inhibitors of the three quorum sensing pathways of Vibrio harveyi (CAI-1, AI-2 and harveyi auto inducer), but isonaamidine A displayed the strongest activity on AI-2 biosensor. Both compounds are new examples of natural QSIs of V. harveyi. These results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs.</description>
<date>2015-10</date>
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