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<title lang=en>BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification</title>
<creator>Cacialli, Pietro</creator>
<creator>Gueguen, Marie-Madeleine</creator>
<creator>Coumailleau, Pascal</creator>
<creator>D'Angelo, Livia</creator>
<creator>Kah, Olivier</creator>
<creator>Lucini, Carla</creator>
<creator>Pellegrini, Elisabeth</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>University of Rennes 1, Inserm</contributor>
<contributor> European Trans Channel Neuroscience Network Program (TC2N)</contributor>
<contributor> INSERM (France)</contributor>
<contributor> University of Rennes 1 (France)</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01359562</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01359562</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01359562</source>
<source>PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0158057. 〈10.1371/journal.pone.0158057〉</source>
<identifier>DOI : 10.1371/journal.pone.0158057</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158057</relation>
<identifier>PUBMED : 27336917</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27336917</relation>
<language>en</language>
<subject lang=en>factor messenger-rna</subject>
<subject lang=en> neurotrophic factor bdnf</subject>
<subject lang=en> central-nervous-system</subject>
<subject lang=en> sex steroid-hormones</subject>
<subject lang=en> radial glial-cells</subject>
<subject lang=en> alzheimers-disease</subject>
<subject lang=en> teleost fish</subject>
<subject lang=en> rat</subject>
<subject lang=en> neurogenesis</subject>
<subject lang=en> mice</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has emerged as an active mediator in many essential functions in the central nervous system of mammals. BDNF plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. Despite the vast literature present in mammals, studies devoted to BDNF in the brain of other animal models are scarse. Zebrafish is a teleost fish widely known for developmental genetic studies and is emerging as model for translational neuroscience research. In addition, its brain shows many sites of adult neurogenesis allowing higher regenerative properties after traumatic injuries. To add further knowledge on neurotrophic factors in vertebrate brain models, we decided to determine the distribution of bdnf mRNAs in the larval and adult zebrafish brain and to characterize the phenotype of cells expressing bdnf mRNAs by means of double staining studies. Our results showed that bdnf mRNAs were widely expressed in the brain of 7 days old larvae and throughout the whole brain of mature female and male zebrafish. In adults, bdnf mRNAs were mainly observed in the dorsal telencephalon, preoptic area, dorsal thalamus, posterior tuberculum, hypothalamus, synencephalon, optic tectum and medulla oblongata. By combining immunohistochemistry with in situ hybridization, we showed that bdnf mRNAs were never expressed by radial glial cells or proliferating cells. By contrast, bdnf transcripts were expressed in cells with neuronal phenotype in all brain regions investigated. Our results provide the first demonstration that the brain of zebrafish expresses bdnf mRNAs in neurons and open new fields of research on the role of the BDNF factor in brain mechanisms in normal and brain repairs situations.</description>
<date>2016</date>
</dc>
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