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<identifier>oai:HAL:hal-01230471v1</identifier>
<datestamp>2018-01-11</datestamp>
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<title lang=en>Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products</title>
<creator>Houël, Emeline</creator>
<creator>Gonzalez, German</creator>
<creator>Bessière, Jean-Marie</creator>
<creator>Odonne, Guillaume</creator>
<creator>Eparvier, Véronique</creator>
<creator>Deharo, Eric</creator>
<creator>Stien, Didier</creator>
<contributor>Ecologie des forêts de Guyane (ECOFOG) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut National de la Recherche Agronomique (INRA) - Université des Antilles et de la Guyane (UAG) - AgroParisTech - Université de Guyane (UG) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Laboratoire de pharmacochimie et pharmacologie pour le développement UMR 152 ; Université Paul Sabatier - Toulouse 3 (UPS)</contributor>
<contributor>Laboratoire des Systèmes d'Information Chimique (LSIC - ENSCM) ; Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>CNRS Guyane (USR 3456) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de Chimie des Substances Naturelles (ICSN) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - PIERRE FABRE - Electricité de France Recherche et Développement (EDF R&D) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0074-0276</source>
<source>EISSN: 1678-8060</source>
<source>Memórias do Instituto Oswaldo Cruz.</source>
<publisher>Instituto Oswaldo Cruz, Ministério da Saúde</publisher>
<identifier>hal-01230471</identifier>
<identifier>http://hal.upmc.fr/hal-01230471</identifier>
<identifier>http://hal.upmc.fr/hal-01230471/document</identifier>
<identifier>http://hal.upmc.fr/hal-01230471/file/0074-0276-mioc-0140332.pdf</identifier>
<source>http://hal.upmc.fr/hal-01230471</source>
<source>Memórias do Instituto Oswaldo Cruz., Instituto Oswaldo Cruz, Ministério da Saúde, 2015, 110 (1), pp.106-113. 〈10.1590/0074-02760140332〉</source>
<identifier>DOI : 10.1590/0074-02760140332</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760140332</relation>
<language>en</language>
<subject lang=en>antifungal agents</subject>
<subject lang=en>antiparasitic agents</subject>
<subject lang=en>Leishmania</subject>
<subject lang=en>peritoneal macrophages</subject>
<subject lang=en>sesquiterpenes</subject>
<subject lang=en>therapeutic switching</subject>
<subject>[CHIM.THER] Chemical Sciences/Medicinal Chemistry</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydro-distilled. Using broth microdilution techniques, the obtained EOs were tested against three strains of dermatophytes (Trichophyton mentagrophytes, Microsporum gypseum and Microsporum canis). To compare the EOs antifungal and antiparasitic effects, the EOs activities against axenic amastigotes of L. amazonensis were concurrently evaluated. For the most promising EOs, their antileishmanial activities against parasites infecting peritoneal macrophages of BALB/c mice were measured. The most interesting antifungal candidates were the EOs from Cymbopogon citratus, Otacanthus azureus and Protium heptaphyllum, whereas O. azureus, Piper hispidum and P. heptaphyllum EOs exhibited the lowest 50% inhibitory concentration (IC 50) values against axenic amastigotes, thus revealing a certain correspondence between both activities. The P. hispidum EO was identified as the most promising product in the results from the infected macrophages model (IC 50 : 4.7 µg/mL, safety index: 8). The most abundant compounds found in this EO were sesquiter-penes, notably curzerene and furanodiene. Eventually, the evaluation of the antidermatophytic activity of EOs appears to be an efficient method for identifying new potential drugs for the treatment of L. amazonensis.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2015-02</date>
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