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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface</title>
<creator>Boulay, Anne-Cécile</creator>
<creator>Saubaméa, Bruno</creator>
<creator>ADAM, Nicolas</creator>
<creator>Chasseigneaux, Stéphanie</creator>
<creator>Mazaré, Noémie</creator>
<creator>Gilbert, Alice</creator>
<creator>Bahin, Mathieu</creator>
<creator>Bastianelli, Leïla</creator>
<creator>Blugeon, Corinne</creator>
<creator>Perrin, Sandrine</creator>
<creator>Pouch, Juliette</creator>
<creator>Ducos, Bertrand</creator>
<creator>Le Crom, Stéphane</creator>
<creator>Genovesio, Auguste</creator>
<creator>Chrétien, Fabrice</creator>
<creator>Declèves, Xavier</creator>
<creator>Laplanche, Jean-Louis</creator>
<creator>Cohen-Salmon, Martine</creator>
<contributor>Analyse des Données à Haut Débit en Génomique (ADHDG) ; Systématique, adaptation, évolution (SAE) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Evolution Paris Seine ; Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Université des Antilles et de la Guyane (UAG)</contributor>
<description>International audience</description>
<source>Cell Discovery</source>
<identifier>hal-01545319</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01545319</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01545319</source>
<source>Cell Discovery, 2017, 3, pp.17005. 〈10.1038/celldisc.2017.5〉</source>
<identifier>DOI : 10.1038/celldisc.2017.5</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/celldisc.2017.5</relation>
<language>en</language>
<subject>[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Astrocytes send out long processes that are terminated by endfeet at the vascular surface and regulate vascular functions as well as homeostasis at the vascular interface. To date, the astroglial mechanisms underlying these functions have been poorly addressed. Here we demonstrate that a subset of messenger RNAs is distributed in astrocyte endfeet. We identified, among this transcriptome, a pool of messenger RNAs bound to ribosomes, the endfeetome, that primarily encodes for secreted and membrane proteins. We detected nascent protein synthesis in astrocyte endfeet. Finally, we determined the presence of smooth and rough endoplasmic reticulum and the Golgi apparatus in astrocyte perivascular processes and endfeet, suggesting for local maturation of membrane and secreted proteins. These results demonstrate for the first time that protein synthesis occurs in astrocyte perivascular distal processes that may sustain their structural and functional polarization at the vascular interface.</description>
<date>2017-03</date>
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