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<publisher>HAL CCSD</publisher>
<title lang=en>Transcriptome analysis reveals the contribution of thermal and the specific effects in cellular response to millimeter wave exposure.</title>
<creator>Habauzit, Denis</creator>
<creator>Le Quément, Catherine</creator>
<creator>Zhadobov, Maxim</creator>
<creator>Martin, Catherine</creator>
<creator>Aubry, Marc</creator>
<creator>Sauleau, Ronan</creator>
<creator>Le Dréan, Yves</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut d'Electronique et de Télécommunications de Rennes (IETR) ; Université de Nantes (UN) - Université de Rennes 1 (UR1) - Institut National des Sciences Appliquées - Rennes (INSA Rennes) - CentraleSupélec - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Plateforme bioinformatique GenOuest [Rennes] ; Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA) ; CentraleSupélec - Université de Rennes 1 (UR1) - Télécom Bretagne - Institut National des Sciences Appliquées (INSA) - Institut National de Recherche en Informatique et en Automatique (Inria) - École normale supérieure - Rennes (ENS Rennes) - Centre National de la Recherche Scientifique (CNRS) - Université de Bretagne Sud (UBS) - CentraleSupélec - Université de Rennes 1 (UR1) - Télécom Bretagne - Institut National des Sciences Appliquées (INSA) - Institut National de Recherche en Informatique et en Automatique (Inria) - École normale supérieure - Rennes (ENS Rennes) - Centre National de la Recherche Scientifique (CNRS) - Université de Bretagne Sud (UBS) - Plateforme Génomique Santé Biogenouest® - Inria Rennes – Bretagne Atlantique ; Institut National de Recherche en Informatique et en Automatique (Inria)</contributor>
<contributor>This work was supported by the French National Research Agency (Agence Nationale de la Recherche, ANR), under grants number 09-RPDOC-003-01 (Bio-CEM project) and number 10-CESA-017-01 (BioREF project).</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01118066</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118066</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118066</source>
<source>PLoS ONE, Public Library of Science, 2013, 9 (10), pp.e109435. 〈10.1371/journal.pone.0109435〉</source>
<identifier>PUBMED : 25302706</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25302706</relation>
<identifier>DOI : 10.1371/journal.pone.0109435</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0109435</relation>
<identifier>PUBMEDCENTRAL : PMC4193780</identifier>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Radiofrequency radiations constitute a new form of environmental pollution. Among them, millimeter waves (MMW) will be widely used in the near future for high speed communication systems. This study aimed therefore to evaluate the biocompatibility of MMW at 60 GHz. For this purpose, we used a whole gene expression approach to assess the effect of acute 60 GHz exposure on primary cultures of human keratinocytes. Controls were performed to dissociate the electromagnetic from the thermal effect of MMW. Microarray data were validated by RT-PCR, in order to ensure the reproducibility of the results. MMW exposure at 20 mW/cm2, corresponding to the maximum incident power density authorized for public use (local exposure averaged over 1 cm2), led to an increase of temperature and to a strong modification of keratinocyte gene expression (665 genes differentially expressed). Nevertheless, when temperature is artificially maintained constant, no modification in gene expression was observed after MMW exposure. However, a heat shock control did not mimic exactly the MMW effect, suggesting a slight but specific electromagnetic effect under hyperthermia conditions (34 genes differentially expressed). By RT-PCR, we analyzed the time course of the transcriptomic response and 7 genes have been validated as differentially expressed: ADAMTS6, NOG, IL7R, FADD, JUNB, SNAI2 and HIST1H1A. Our data evidenced a specific electromagnetic effect of MMW, which is associated to the cellular response to hyperthermia. This study raises the question of co-exposures associating radiofrequencies and other environmental sources of cellular stress.</description>
<date>2013-11-30</date>
<contributor>ANR-10-CESA-0017, BioREF, Biomarqueurs d'Exposition aux Rayonnements Electromagnétiques du Futur(2010)</contributor>
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