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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Tuberculosis and histoplasmosis among human immunodeficiency virus-infected patients: a comparative study.</title>
<creator>Adenis, Antoine</creator>
<creator>Nacher, Mathieu</creator>
<creator>Hanf, Matthieu</creator>
<creator>Basurko, Célia</creator>
<creator>Dufour, Julie</creator>
<creator>Huber, Florence</creator>
<creator>Aznar, Christine</creator>
<creator>Carme, Bernard</creator>
<creator>Couppié, Pierre</creator>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Epidémiologie des parasitoses et mycoses tropicales ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de Dermatologie et Vénérologie ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie ; Centre Hospitalier de Cayenne</contributor>
<contributor>Investissement d'Avenir from the ANR</contributor>
<description>International audience</description>
<source>ISSN: 0002-9637</source>
<source>American Journal of Tropical Medicine and Hygiene</source>
<publisher>American Society of Tropical Medicine and Hygiene</publisher>
<identifier>inserm-01065027</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01065027</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01065027/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01065027/file/2014_Adenis_-_Tuberculosis_and_Histoplasmosis_among_HIV.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01065027</source>
<source>American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2014, 90 (2), pp.216-23. 〈10.4269/ajtmh.13-0084〉</source>
<identifier>DOI : 10.4269/ajtmh.13-0084</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.13-0084</relation>
<identifier>PUBMED : 24394475</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24394475</relation>
<language>en</language>
<subject lang=en>HIV</subject>
<subject lang=en>AIDS</subject>
<subject lang=en>Tuberculosis</subject>
<subject lang=en>Histoplasmosis</subject>
<subject lang=en>French Guiana</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>In disease-endemic areas, histoplasmosis is the main differential diagnosis for tuberculosis among human immunodeficiency virus (HIV)-infected patients. However, no study has compared the two diseases. Thus, the objective of this study was to compare tuberculosis and histoplasmosis in HIV-infected patients. A population of 205 HIV-infected patients (99 with tuberculosis and 106 with histoplasmosis) hospitalized in Cayenne, French Guiana during January 1, 1997-December 31, 2008 were selected retrospectively from the French Hospital Database on HIV. Multivariate analysis showed that tuberculosis was associated with cough (adjusted odds ratio [AOR] = 0.20, 95% confidence interval [CI] = 0.05-0.73) and a C-reactive protein level > 70 mg/L (AOR = 0.98, 95% CI = 0.97-0.99). Variables associated with disseminated histoplasmosis were a γ-glutamyl transferase level > 72 IU/L (AOR = 4.99, 95% CI = 1.31-18.99), origin from French Guiana (AOR = 5.20, 95% CI = 1.30-20.73), disseminated localization (AOR = 6.40, 95% CI = 1.44-28.45), a concomitant opportunistic infection (AOR = 6.71, 95% CI = 1.50-29.96), a neutrophil count < 2,750 cells/mm(3) (AOR = 10.54, 95% CI = 2.83-39.24), a CD4 cell count < 60 cells/mm(3) (AOR = 11.62, 95% CI = 2.30-58.63), and a platelet count < 150,000/mm(3) (AOR = 19.20, 95% CI = 3.35-110.14). Tuberculosis and histoplasmosis have similarities, but some factors show a greater association with one of these diseases. Thus, adapted therapeutic choices can be made by using simple clinical and paraclinical criteria.</description>
<date>2014-02</date>
</dc>
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