untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:34:24Z</responseDate>
<request identifier=oai:HAL:hal-00851184v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-00851184v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-CLERMONT1</setSpec>
<setSpec>collection:UNIV-STRASBG1</setSpec>
<setSpec>collection:UNIV-STRASBG</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:CURIE</setSpec>
<setSpec>collection:FNCLCC</setSpec>
<setSpec>collection:CJP</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:PRES_CLERMONT</setSpec>
<setSpec>collection:IRSET-VCER</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:INC-CNRS</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:PSL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:UNIV-PSUD</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells.</title>
<creator>Merle, Patrick</creator>
<creator>Evrard, Bertrand</creator>
<creator>Petitjean, Anne</creator>
<creator>Lehn, Jean-Marie</creator>
<creator>Teulade-Fichou, Marie-Paule</creator>
<creator>Chautard, Emmanuel</creator>
<creator>De Cian, Anne</creator>
<creator>Guittat, Lionel</creator>
<creator>Tran, Phong Lan Thao</creator>
<creator>Mergny, Jean-Louis</creator>
<creator>Verrelle, Pierre</creator>
<creator>Tchirkov, Andreï</creator>
<contributor>Université d'Auvergne - Clermont-Ferrand I (UdA)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Queen's University Kingston ; Queen's University</contributor>
<contributor>Institut de Science et d'ingénierie supramoléculaires (ISIS) ; Université Louis Pasteur - Strasbourg I - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Conception, Synthèse et Vectorisation de Biomolécules ; Université Paris-Sud - Paris 11 (UP11) - UMR 176-CNRS - le Laboratoire Raymond-Latarget d'Orsay - INSTITUT CURIE</contributor>
<contributor>Faculté de Médecine - Clermont-Ferrand ; Université d'Auvergne - Clermont-Ferrand I (UdA)</contributor>
<contributor>Centre Jean Perrin ; CRLCC Jean Perrin</contributor>
<description>International audience</description>
<source>ISSN: 1535-7163</source>
<source>EISSN: 1538-8514</source>
<source>Molecular Cancer Therapeutics</source>
<publisher>American Association for Cancer Research</publisher>
<identifier>hal-00851184</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00851184</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00851184</source>
<source>Molecular Cancer Therapeutics, American Association for Cancer Research, 2011, 10 (10), pp.1784-95. 〈10.1158/1535-7163.MCT-10-0664〉</source>
<identifier>DOI : 10.1158/1535-7163.MCT-10-0664</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1158/1535-7163.MCT-10-0664</relation>
<identifier>PUBMED : 21987532</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/21987532</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The aim of this study was to test in vitro the efficacy of TAC, an original G-quadruplex ligand, as a potential radiosensitizing agent for glioblastoma multiforme (GBM). Two human radioresistant telomerase-positive GBM cell lines (SF763 and SF767) were analyzed, with and without TAC treatment, for telomere length, cell proliferation, apoptosis, cell-cycle distribution, gene expression, cytogenetic aberrations, clonogenic survival assay, 53BP1 immunofluorescence staining, and γH2AX phosphorylation. We found that low concentrations of TAC (0.5 and 1 μmol/L) inhibited the proliferation of GBM cells in a concentration-dependent manner after only 1 week of treatment, with minimal effects on cell cycle and apoptosis. TAC treatment had no visible effect on average telomere length but modified expression levels of telomere-related genes (hTERT, TRF1, and TRF2) and induced concentration-dependent DNA damage response and dicentric chromosomes. Survival curves analysis showed that exposure to nontoxic, subapoptotic concentrations of TAC enhanced radiation-induced killing of GBM cells. Analysis of DNA repair after irradiation revealed delayed repair kinetics in GBM cells treated with TAC. Furthermore, the combined treatment (TAC and radiation) significantly increased the frequency of chromosomal aberrations as compared with radiation alone. These findings provide the first evidence that exposure to a G4 ligand radiosensitizes human glioblastoma cells and suggest the prospect of future therapeutic applications.</description>
<date>2011-10</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
