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<datestamp>2017-12-21</datestamp>
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<title lang=en>Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation.</title>
<creator>Ferriere, François</creator>
<creator>Habauzit, Denis</creator>
<creator>Pakdel, Farzad</creator>
<creator>Saligaut, Christian</creator>
<creator>Flouriot, Gilles</creator>
<contributor>TREC : Transcription, Environment and Cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Agence National de la Recherche (http://www.agence-nationale-recherche.fr/, project NEED: CES 2008-011) ; CRITT-Santé Bretagne (http://www.critt-sante.fr/, contract: 08007968) ; INERIS (http://www.ineris.fr/, project NEMO: 189).</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00865332</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00865332</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00865332/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00865332/file/PMID_23825704.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00865332</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e69081. 〈10.1371/journal.pone.0069081〉</source>
<identifier>DOI : 10.1371/journal.pone.0069081</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0069081</relation>
<identifier>PUBMED : 23825704</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23825704</relation>
<language>en</language>
<subject lang=en>apoptosis</subject>
<subject lang=en>cell membranes</subject>
<subject lang=en>estrogens</subject>
<subject lang=en>phenols</subject>
<subject lang=en>phosphorylation</subject>
<subject lang=en>small interfering RNA</subject>
<subject lang=en>transfection</subject>
<subject lang=en>tyrosine</subject>
<subject>[SDV.BC] Life Sciences [q-bio]/Cellular Biology</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Many studies have reported proliferative, differentiating or protective effects of estradiol, notably through estrogen receptor alpha (ERα). On the contrary, the ligand-independent action of ERα is currently poorly documented notably in cell protection. The stable transfection of wild type, substituted or truncated form of ERα in PC12 cells (ERα negative cell line) lead the specific study of its ligand-independent action. Hence, we demonstrate here that, in the absence of E2, the expression of ERα prevents cells from apoptosis induced by serum deprivation. This protection is not due to an ERE-mediated transcription and does not require either AF-1 or AF-2 transactivation functions. It is afforded to the Y537 residue of ERα and activation of c-Src/Stat3 signaling pathway.</description>
<date>2013</date>
</dc>
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