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<title lang=en>Development of liquid chromatography methods coupled to mass spectrometry for the analysis of substances with a wide variety of polarity in meconium.</title>
<creator>Meyer-Monath, Marie</creator>
<creator>Chatellier, Claudine</creator>
<creator>Cabooter, Deirdre</creator>
<creator>Rouget, Florence</creator>
<creator>Morel, Isabelle</creator>
<creator>Lestremau, Francois</creator>
<contributor>Institut National de l'Environnement Industriel et des Risques (INERIS)</contributor>
<contributor>Katholieke Universiteit Leuven (KU Leuven)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Foie, métabolismes et cancer ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This work was funded par the Programme Hospitalier de Recherche Clinique national (PHRC) 2010 assigned to Rennes University Hospital (CHU) for the PENEW project. It was supported by Dr. Florence Rouget (Brittany Registry of Congenital Malformations) in collaboration with the INSERM unities 1085 and 991 of Institut de Recherche en Santé, Environnement et Travail (IRSET) (Université Rennes I), and the Centre de Ressources Biologiques (CRB) of Centre d’Investigations Cliniques (CIC) of CHU de Rennes.The authors thank Dr. Loget of anatomical pathology service of Centre Hospitalier Universitaire (CHU) de Rennes for providing meconium samples.</contributor>
<description>International audience</description>
<source>ISSN: 0039-9140</source>
<source>Talanta</source>
<publisher>Elsevier</publisher>
<identifier>hal-01141722</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01141722</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01141722/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01141722/file/Development%20of%20liquid%20chromatography%20%281%29.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01141722</source>
<source>Talanta, Elsevier, 2015, 138, pp.231-239. 〈10.1016/j.talanta.2015.02.058〉</source>
<identifier>PUBMED : 25863396</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25863396</relation>
<identifier>DOI : 10.1016/j.talanta.2015.02.058</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2015.02.058</relation>
<language>en</language>
<subject lang=en>Reversed phase</subject>
<subject lang=en>Micropollutants</subject>
<subject lang=en>HILIC</subject>
<subject lang=en>Meconium</subject>
<subject lang=en>LC/MS/MS</subject>
<subject lang=en>Ion exchange</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Meconium is the first fecal excretion of newborns. This complex accumulative matrix allows assessing the exposure of the fetus to xenobiotics during the last 6 months of pregnancy. To determine the eventual effect of fetal exposure to micropollutants in this matrix, robust and sensitive analytical methods must be developed. This article describes the method development of liquid chromatography methods coupled to triple quadrupole mass spectrometry for relevant pollutants. The 28 selected target compounds had different physico-chemical properties from very polar (glyphosate) to non-polar molecules (pyrethroids). Tests were performed with three different types of columns: reversed phase, ion exchange and HILIC. As a unique method could not be determined for the simultaneous analysis of all compounds, three columns were selected and suitable chromatographic methods were optimized. Similar results were noticed for the separation of the target compounds dissolved in either meconium extract or solvent for reversed phase and ion exchange columns. However, for HILIC, the matrix had a significant influence on the peak shape and robustness of the method. Finally, the analytical methods were applied to “real” meconium samples.</description>
<date>2015-06-01</date>
</dc>
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