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<identifier>oai:HAL:hal-01137567v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
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<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia</title>
<creator>Waltz, Xavier</creator>
<creator>Hedreville, Mona</creator>
<creator>Sinnapah, Stéphane</creator>
<creator>Lamarre, Yann</creator>
<creator>Soter, Valérie</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Beltan, Eric</creator>
<creator>Chalabi, Tawfik</creator>
<creator>Chout, Roger</creator>
<creator>Hue, Olivier</creator>
<creator>Mougenel, Danièle</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Connes, Philippe</creator>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CHU de Pointe-à-Pitre ; CHU de Pointe-à-Pitre</contributor>
<contributor>Laboratoire d'hématologie et immunologie ; CHU Pointe-à-Pitre</contributor>
<description>International audience</description>
<source>ISSN: 1386-0291</source>
<source>Clinical Hemorheology and Microcirculation</source>
<publisher>IOS Press</publisher>
<identifier>hal-01137567</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01137567</identifier>
<source>https://hal.univ-antilles.fr/hal-01137567</source>
<source>Clinical Hemorheology and Microcirculation, IOS Press, 2012, 52 (1), pp.1-12</source>
<language>en</language>
<subject lang=en>red blood cell aggregation</subject>
<subject lang=en>red blood cell deformability</subject>
<subject lang=en>sickle cell disease</subject>
<subject lang=en>physical activity</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Because of the metabolic changes induced by a physical activity, the hemorheological properties of patients with sickle cell anemia could be further impaired and increase the risks for vaso-occlusive complications. However, few studies suggest that moderate physical activity could be beneficial rather than harmful in patients with sickle cell anemia (SCA). However, the definition of what can be considered as a moderate physical activity in SCA patients is imprecise. The present study tested the effects of a short incremental cycling exercise test conducted until the first ventilatory threshold on different biomarkers. Hematological and hemorheological parameters were compared between 8 patients with SCA and 13 healthy subjects (CONT) before, immediately after the end of the exercise and at 12, 36 and 60 hours after the exercise. We observed no significant hematological or hemorheological alteration induced by the exercise in the two groups. However, the exercise resulted in a delayed improvement of the red blood cell disaggregation threshold at 36 and 60 hrs after exercise in the SCA group which was paralleled to the decrease in the platelet count in this group. The present study suggests that such an exercise might be beneficial for microcirculatory blood flow.</description>
<date>2012-03-13</date>
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