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<publisher>HAL CCSD</publisher>
<title lang=fr>Diagnostic de l'allergie alimentaire à la noisette chez l'enfant : il faut rester prudent !</title>
<creator>Evrard, Bertrand</creator>
<creator>Michaud, E.</creator>
<creator>Rondet, B.</creator>
<creator>Tridon, Arlette</creator>
<creator>Fauquert, J. L.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Unité de Nutrition Humaine - Clermont Auvergne (UNH) ; Université Clermont Auvergne (UCA) - Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] (INRA Auvergne/Rhône-Alpes)</contributor>
<contributor>Unité d'allergologie de l'enfant ; Centre Hospitalier Universitaire Estaing</contributor>
<source>ISSN: 1877-0320</source>
<source>Revue francaise d'allergologie</source>
<publisher>Elsevier</publisher>
<identifier>hal-01056803</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01056803</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01056803</source>
<source>Revue francaise d'allergologie, Elsevier, 2013, 53 (1), pp.51-53. 〈10.1016/j.reval.2012.10.004〉</source>
<identifier>DOI : 10.1016/j.reval.2012.10.004</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reval.2012.10.004</relation>
<language>fr</language>
<subject>[SDV.SA] Life Sciences [q-bio]/Agricultural sciences</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Diagnosing of hazelnut allergy was recently enhanced by value of serum specific IgE versus recombinant fractions, Cor a 1 and Cor a 8. Their positivity could be linked with clinical benignity for Cor a 1 and severity for Cor a 8. The authors report four cases contradicting this aphorism. The oral food challenge to hazelnut induced in these patients a severe clinical response with a severe increase of serum tryptase at the end of the challenge. The level of serum specific IgE to Cor a 8 was negative (or very low). For Cor a 1 the level was very high or low. We discuss the clinical relevance of the aphorism "Cor a 1 = benignity; Cor a 8 = severity", which use should be modulated in clinical practice. Other allergenic fractions could account for these cases. (c) 2012 Elsevier Masson SAS. All rights reserved.</description>
<date>2013</date>
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