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<title lang=en>DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.</title>
<creator>Gu, Dan</creator>
<creator>Turesky, Robert J.</creator>
<creator>Tao, Yeqing</creator>
<creator>Langouët, Sophie</creator>
<creator>Nauwelaers, Gwendoline</creator>
<creator>Yuan, Jian-Min</creator>
<creator>Yee, Douglas</creator>
<creator>Yu, Mimi C.</creator>
<contributor>New York State Department of Health ; New York State Department of Health</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Division of Cancer Control and Population Sciences ; University of Pittsburgh Cancer Institute - University of Pittsburgh Graduate School of Public Health</contributor>
<contributor>Masonic Cancer Center ; University of Minnesota [Minneapolis]</contributor>
<contributor>the National Cancer Institute; Inserm; la Ligue contre le cancer; la Région Bretagne</contributor>
<description>International audience</description>
<source>ISSN: 0143-3334</source>
<source>EISSN: 1460-2180</source>
<source>Carcinogenesis</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-00682453</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682453</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00682453</source>
<source>Carcinogenesis, Oxford University Press (OUP), 2012, 33 (1), pp.124-30. 〈10.1093/carcin/bgr252〉</source>
<identifier>DOI : 10.1093/carcin/bgr252</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/carcin/bgr252</relation>
<identifier>PUBMED : 22072616</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22072616</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Some epidemiological investigations have revealed that frequent consumption of well-done cooked meats and tobacco smoking are risk factors for breast cancer in women. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed in well-done cooked meat, and 4-aminobiphenyl (4-ABP) is an aromatic amine that arises in tobacco smoke and occurs as a contaminant in the atmosphere. Both compounds are rodent mammary carcinogens, and putative DNA adducts of PhIP and 4-ABP have been frequently detected, by immunohistochemistry (IHC) or (32)P-post-labeling methods, in mammary tissue of USA women. Because of these findings, PhIP and 4-ABP have been implicated as causal agents of human breast cancer. However, the biomarker data are controversial: both IHC and (32)P-post-labeling are non-selective screening methods and fail to provide confirmatory spectral data. Consequently, the identities of the lesions are equivocal. We employed a specific and sensitive liquid chromatography/mass spectrometry (MS) method, to screen tumor-adjacent normal mammary tissue for DNA adducts of PhIP and 4-ABP. Only 1 of 70 biopsy samples obtained from Minneapolis, Minnesota breast cancer patients contained a PhIP-DNA adduct. The level was three adducts per 10(9) nucleotides, a level that is 100-fold lower than the mean level of PhIP adducts reported by IHC or (32)P-post-labeling methods. The occurrence of 4-ABP-DNA adducts was nil in those same breast tissues. Our findings, derived from a specific mass spectrometry method, signify that PhIP and 4-ABP are not major DNA-damaging agents in mammary tissue of USA women and raise questions about the roles of these chemicals in breast cancer.</description>
<date>2012-01</date>
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