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<publisher>HAL CCSD</publisher>
<title lang=en>DNA recombination. Recombination initiation maps of individual human genomes.</title>
<creator>Pratto, Florencia</creator>
<creator>Brick, Kevin</creator>
<creator>Khil, Pavel</creator>
<creator>Smagulova, Fatima</creator>
<creator>Petukhova, Galina V</creator>
<creator>Camerini-Otero, R Daniel</creator>
<contributor>Genetics and Biochemistry Branch ; National Institute of Health (NIH) - National Institute of Diabetes, Digestive and Kidney Diseases</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Department of Biochemistry and Molecular Biology ; Uniformed Services University of the Health Sciences</contributor>
<description>International audience</description>
<source>ISSN: 0036-8075</source>
<source>EISSN: 1095-9203</source>
<source>Science</source>
<publisher>American Association for the Advancement of Science</publisher>
<identifier>hal-01123717</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01123717</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01123717</source>
<source>Science, American Association for the Advancement of Science, 2014, 346 (6211), pp.1256442. 〈10.1126/science.1256442〉</source>
<identifier>PUBMED : 25395542</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25395542</relation>
<identifier>DOI : 10.1126/science.1256442</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1256442</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here, we present high-resolution maps of meiotic DSBs in individual human genomes. Comparing DSB maps between individuals shows that along with DNA binding by PRDM9, additional factors may dictate the efficiency of DSB formation. We find evidence for both GC-biased gene conversion and mutagenesis around meiotic DSB hotspots, while frequent colocalization of DSB hotspots with chromosome rearrangement breakpoints implicates the aberrant repair of meiotic DSBs in genomic disorders. Furthermore, our data indicate that DSB frequency is a major determinant of crossover rate. These maps provide new insights into the regulation of meiotic recombination and the impact of meiotic recombination on genome function.</description>
<date>2014-11-14</date>
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