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<publisher>HAL CCSD</publisher>
<title lang=en>Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers.</title>
<creator>Connes, Philippe</creator>
<creator>Lamarre, Yann</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Waltz, Xavier</creator>
<creator>Mougenel, Danièle</creator>
<creator>Mukisi-Mukaza, Martin</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Tarer, Vanessa</creator>
<creator>Tressières, Benoit</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Romana, Marc</creator>
<contributor>Laboratory of Excellence GR-Ex " The red cell : from genesis to death " ; PRES Sorbonne Paris Cité</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00922105</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922105</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922105/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922105/file/2013_Connes_-_Decreased_Hematocrit.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00922105</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e79680. 〈10.1371/journal.pone.0079680〉</source>
<identifier>DOI : 10.1371/journal.pone.0079680</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0079680</relation>
<identifier>PUBMED : 24223994</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24223994</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (ULC+) - but with no leg ulcers at the time of the study - were recruited. All patients were in steady state condition. Blood was sampled to perform hematological, biochemical (hemolytic markers) and hemorheological analyses (blood viscosity, red blood cell deformability and aggregation properties). The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each subject. Patients from the ULC+ group were older than patients from the ULC- group. Anemia (red blood cell count, hematocrit and hemoglobin levels) was more pronounced in the ULC+ group. Lactate dehydrogenase level was higher in the ULC+ group than in the ULC- group. Neither blood viscosity, nor RBC aggregation properties differed between the two groups. HVR was lower and RBC deformability tended to be reduced in the ULC+ group. Our study confirmed increased hemolytic rate and anemia in SCA patients with leg ulcers recurrence. Furthermore, our data suggest that although systemic blood viscosity is not a major factor involved in the pathophysiology of this complication, decreased red blood cell oxygen transport efficiency (i.e., low hematocrit/viscosity ratio) may play a role.</description>
<date>2013</date>
</dc>
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